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Tbio
CIITA
MHC class II transactivator

Protein Summary
Description
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381835
  • ENSP00000371257
  • ENSG00000179583

Symbol
  • MHC2TA
  • C2TA
  • NLRA
  • MHC2TA
  • CIITAIV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
hub protein
0.82
biological process
0.77
kinase
0.75
biological term
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.62   (req: < 5)
Gene RIFs: 154   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.62   (req: >= 5)
Gene RIFs: 154   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
68.4
nasopharyngeal neoplasm
1
1
0
1.1
46.2
1
1
0
1.1
46.2
monocyte percentage of leukocytes
1
1
1
32.2
1
1
0
2.8
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
68.4
nasopharyngeal neoplasm
0
1.1
46.2
0
1.1
46.2
monocyte percentage of leukocytes
1
32.2
0
2.8
2
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (23)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (281)
1 – 10 of 281
RFX5
Tbio
Family: TF
Novelty: 0.02002111
Score: 0.992
Data Source: STRINGDB
HLA-DRA
Tbio
Novelty: 0.0060214
Score: 0.977
Data Source: STRINGDB
RFXANK
Tbio
Novelty: 0.00355465
Score: 0.966
Data Source: STRINGDB
HLA-DQA1
Tbio
Novelty: 0.00077488
Score: 0.965
Data Source: STRINGDB
IRF1
Tbio
Family: TF
Novelty: 0.00099983
Score: 0.96
Data Source: STRINGDB
IRF8
Tbio
Family: TF
Novelty: 0.00330143
Score: 0.955
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.953
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.953
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.953
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  472.62

PubMed score by year
PubTator Score  346.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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