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Tchem
MC5R
Melanocortin receptor 5

Protein Summary
Description
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324750
  • ENSP00000318077
  • ENSG00000176136
  • ENST00000589410
  • ENSP00000468086

Symbol
  • MC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
0.73
ligand (protein)
0.68
disease perturbation
0.56
cell type or tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.59   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.59   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 84
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
afamelanotide
chemical structure image
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (155)
1 – 10 of 155
POMC
Tbio
Novelty: 0.00002654
Score: 0.993
Data Source: Reactome,STRINGDB
NPS
Tbio
Novelty: 0.00011983
Score: 0.972
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.00017805
Score: 0.949
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00005614
Score: 0.926
Data Source: STRINGDB
GPR176
Tdark
Family: GPCR
Novelty: 0.43322356
Score: 0.924
Data Source: STRINGDB
NPSR1
Tchem
Family: GPCR
Novelty: 0.00598831
Score: 0.922
Data Source: STRINGDB
GLP1R
Tclin
Family: GPCR
Novelty: 0.00098883
Score: 0.921
Data Source: STRINGDB
CRHR1
Tclin
Family: GPCR
Novelty: 0.00121307
Score: 0.92
Data Source: STRINGDB
GCGR
Tclin
Family: GPCR
Novelty: 0.00450775
Score: 0.917
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00259764
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  111.59

PubMed score by year
PubTator Score  154.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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