Tbio TNFSF8 Tumor necrosis factor ligand superfamily member 8

Protein Summary

Description

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• P32971
• O43404

Gene Name

• TNFSF8

Ensembl ID

• ENST00000223795
• ENSP00000223795
• ENSG00000106952

Symbol

• CD30L
• CD30LG
• CD153
• CD30L
• CD30LG
• TNLG3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.65
gene perturbation	0.63
tissue	0.62
protein domain	0.58
tissue sample	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.92   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 428   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.92   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0