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Tbio
TNFSF8
Tumor necrosis factor ligand superfamily member 8

Protein Summary
Description
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223795
  • ENSP00000223795
  • ENSG00000106952

Symbol
  • CD30L
  • CD30LG
  • CD153
  • CD30L
  • CD30LG
  • TNLG3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.65
gene perturbation
0.63
tissue
0.62
protein domain
0.58
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.06   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.06   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (92)
1 – 10 of 92
DCBLD1
Tdark
Novelty: 0.40223464
p_int: 0.999999664
p_ni: 3.35e-7
p_wrong: 1e-9
Data Source: BioPlex
CDON
Tbio
Novelty: 0.00215307
p_int: 0.999999063
p_ni: 9.37e-7
Data Source: BioPlex
F5
Tbio
Novelty: 0.00193441
p_int: 0.999931114
p_ni: 0.000051939
p_wrong: 0.000016947
Score: 0.229
Data Source: BioPlex,STRINGDB
RYK
Tbio
Family: Kinase
Novelty: 0.01357796
p_int: 0.999911726
p_ni: 0.000088203
p_wrong: 7.1e-8
Data Source: BioPlex
TAMM41
Tbio
Family: Enzyme
Novelty: 0.08219178
p_int: 0.99989957
p_ni: 0.000100419
p_wrong: 1.1e-8
Data Source: BioPlex
NEK3
Tchem
Family: Kinase
Novelty: 0.09841828
p_int: 0.999864626
p_ni: 0.000044569
p_wrong: 0.000090805
Score: 0.173
Data Source: BioPlex,STRINGDB
ULBP2
Tbio
Novelty: 0.02287726
p_int: 0.999414182
p_ni: 0.000585818
Data Source: BioPlex
ATR
Tchem
Family: Kinase
Novelty: 0.00246592
p_int: 0.999337896
p_ni: 0.000662104
Data Source: BioPlex
ULBP3
Tbio
Novelty: 0.05429408
p_int: 0.998803442
p_ni: 0.001196557
p_wrong: 1e-9
Data Source: BioPlex
EFNB3
Tbio
Novelty: 0.01171599
p_int: 0.998174847
p_ni: 0.00182515
p_wrong: 3e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  70.06

PubMed score by year
PubTator Score  48.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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