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Tbio
TNFSF8
Tumor necrosis factor ligand superfamily member 8

Protein Summary
Description
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223795
  • ENSP00000223795
  • ENSG00000106952

Symbol
  • CD30L
  • CD30LG
  • CD153
  • CD30L
  • CD30LG
  • TNLG3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.65
gene perturbation
0.63
tissue
0.62
protein domain
0.58
tissue sample
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.24   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.24   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
93.4
5
5
0
1.7
92.7
2
2
0
1.4
92.1
3
2
0
1.6
90
eosinophil percentage of leukocytes
2
2
2
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.4
0
1.7
92.7
0
1.4
92.1
0
1.6
90
eosinophil percentage of leukocytes
2
89.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 8
VGNC:4886
464686
Macaque
TNF superfamily member 8
702944
Mouse
MGI:88328
21949
Rat
RGD:1590403
683163
Dog
TNF superfamily member 8
VGNC:47673
612608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 8
Macaque
TNF superfamily member 8
Mouse
Rat
Dog
TNF superfamily member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P32971-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (92)
1 – 10 of 92
DCBLD1
Tbio
Novelty:  0.21754882
p_int:  0.999999664
p_ni:  3.35e-7
p_wrong:  1e-9
Data Source:  BioPlex
CDON
Tbio
Novelty:  0.00447262
p_int:  0.999999063
p_ni:  9.37e-7
Data Source:  BioPlex
F5
Tbio
Novelty:  0.00161772
p_int:  0.999931114
p_ni:  0.000051939
p_wrong:  0.000016947
Score:  0.229
Data Source:  BioPlex,STRINGDB
RYK
Tbio
Family:  Kinase
Novelty:  0.00910227
p_int:  0.999911726
p_ni:  0.000088203
p_wrong:  7.1e-8
Data Source:  BioPlex
TAMM41
Tbio
Family:  Enzyme
Novelty:  0.06004824
p_int:  0.99989957
p_ni:  0.000100419
p_wrong:  1.1e-8
Data Source:  BioPlex
NEK3
Tchem
Family:  Kinase
Novelty:  0.09580866
p_int:  0.999864626
p_ni:  0.000044569
p_wrong:  0.000090805
Score:  0.173
Data Source:  BioPlex,STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
p_int:  0.999414182
p_ni:  0.000585818
Data Source:  BioPlex
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
p_int:  0.999337896
p_ni:  0.000662104
Data Source:  BioPlex
ULBP3
Tbio
Novelty:  0.0320239
p_int:  0.998803442
p_ni:  0.001196557
p_wrong:  1e-9
Data Source:  BioPlex
EFNB3
Tbio
Novelty:  0.0120367
p_int:  0.998174847
p_ni:  0.00182515
p_wrong:  3e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  81.24

PubMed score by year
PubTator Score  48.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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