Tbio CD70 CD70 antigen

Protein Summary

Description

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P32970
• B4DPR8
• Q53XX4
• Q96J57

Gene Name

• CD70

Ensembl ID

• ENST00000245903
• ENSP00000245903
• ENSG00000125726
• ENST00000423145
• ENSP00000395294

Symbol

• CD27L
• CD27LG
• TNFSF7
• CD27L
• LPFS3
• CD27-L
• CD27LG
• TNFSF7
• TNLG8A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.84
cell type or tissue	0.81
biological term	0.66
disease	0.63
tissue	0.61

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.51   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 759   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.51   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 759   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (5)

Reactome (4)

KEGG (1)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	TNFR2 non-canonical NF-kB pathway	101 targets	R-HSA-5668541
Reactome	TNFs bind their physiological receptors	28 targets	R-HSA-5669034

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
TNFR2 non-canonical NF-kB pathway	101 targets	R-HSA-5668541
TNFs bind their physiological receptors	28 targets	R-HSA-5669034

Gene Ontology Terms (13)

Functions (4)

Components (3)

Processes (6)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
protease binding	Inferred from Physical Interaction (IPI)	BHF-UCL
signaling receptor binding	Traceable Author Statement (TAS)	ProtInc
cytokine activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
tumor necrosis factor receptor binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (150)

Explore Interacting Targets

1 – 10 of 150

• See Interactions on String-DB

KDM8

Tbio

Family: Epigenetic

Novelty: 0.01809928

p_int: 0.999997964

p_ni: 0.000001363

p_wrong: 6.73e-7

Data Source: BioPlex

TNFRSF13B

Tbio

Novelty: 0.00443808

p_int: 0.999996663

p_ni: 0.00000151

p_wrong: 0.000001827

Score: 0.459

Data Source: BioPlex,STRINGDB

CD27

Tbio

Novelty: 0.00109406

p_int: 0.999982532

p_ni: 0.00001164

p_wrong: 0.000005827

Score: 0.994

Data Source: BioPlex,Reactome,STRINGDB

SEC14L1

Tbio

Novelty: 0.17045632

p_int: 0.999965226

p_ni: 0.000028311

p_wrong: 0.000006463

Data Source: BioPlex

TNFRSF17

Tbio

Novelty: 0.00587499

p_int: 0.999956133

p_ni: 0.000012136

p_wrong: 0.000031731

Score: 0.353

Data Source: BioPlex,STRINGDB

TAMM41

Tbio

Family: Enzyme

Novelty: 0.08219178

p_int: 0.999942466

p_ni: 0.000057533

p_wrong: 2e-9

Data Source: BioPlex

FANCG

Tbio

Novelty: 0.00411649

p_int: 0.999868

p_ni: 0.000127717

p_wrong: 0.000004283

Data Source: BioPlex

NR2C2

Tchem

Family: NR

Novelty: 0.00578325

p_int: 0.999825023

p_ni: 0.000001318

p_wrong: 0.000173659

Score: 0.177

Data Source: BioPlex,STRINGDB

PDXDC1

Tdark

Family: Enzyme

Novelty: 0.43701506

p_int: 0.999818703

p_ni: 0.000181297

Data Source: BioPlex

UTP20

Tbio

Novelty: 0.03742259

p_int: 0.999723741

p_ni: 0.000276259

Data Source: BioPlex

Publication Statistics

PubMed Score  235.51

PubMed score by year

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PubTator Score  156.36

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQD

1-70

PRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSI

70-140

SLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP

140-193

MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP

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Uniprot Keyword

Alternative splicing
Complete proteome
Cytokine
Disulfide bond
Glycoprotein
Membrane
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix