Protein Summary
Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
- ENST00000245903
- ENSP00000245903
- ENSG00000125726
- ENST00000423145
- ENSP00000395294
- CD27L
- CD27LG
- TNFSF7
- CD27L
- LPFS3
- CD27-L
- CD27LG
- TNFSF7
- TNLG8A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.84 | ||
cell type or tissue | 0.81 | ||
biological term | 0.66 | ||
disease | 0.63 | ||
tissue | 0.61 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 268.87 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 759 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 268.87 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 759 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | CD70 molecule | 701080 | ||||||
Mouse | MGI:1195273 | 21948 | ||||||
Rat | RGD:1588573 | 301132 | ||||||
Dog | CD70 molecule | VGNC:38970 | 485018 | |||||
Horse | CD70 molecule | VGNC:16278 | 100065854 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | CD70 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD70 molecule | |||||
Horse | CD70 molecule | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | TNFR2 non-canonical NF-kB pathway | ||||
Reactome | TNFs bind their physiological receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
TNFR2 non-canonical NF-kB pathway | ||||
TNFs bind their physiological receptors | ||||
Gene Ontology Terms (13)
Functions (4)
Components (3)
Processes (6)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (150)
1 – 10 of 150
KDM8
Family: Epigenetic
Novelty: 0.03368031
p_int: 0.999997964
p_ni: 0.000001363
p_wrong: 6.73e-7
Data Source: BioPlex
TNFRSF13B
Novelty: 0.00338954
p_int: 0.999996663
p_ni: 0.00000151
p_wrong: 0.000001827
Score: 0.459
Data Source: BioPlex,STRINGDB
CD27
Novelty: 0.00090508
p_int: 0.999982532
p_ni: 0.00001164
p_wrong: 0.000005827
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
SEC14L1
Novelty: 0.09562071
p_int: 0.999965226
p_ni: 0.000028311
p_wrong: 0.000006463
Data Source: BioPlex
TNFRSF17
Novelty: 0.00222663
p_int: 0.999956133
p_ni: 0.000012136
p_wrong: 0.000031731
Score: 0.353
Data Source: BioPlex,STRINGDB
TAMM41
Family: Enzyme
Novelty: 0.06004824
p_int: 0.999942466
p_ni: 0.000057533
p_wrong: 2e-9
Data Source: BioPlex
FANCG
Novelty: 0.00908902
p_int: 0.999868
p_ni: 0.000127717
p_wrong: 0.000004283
Data Source: BioPlex
NR2C2
Family: NR
Novelty: 0.00392355
p_int: 0.999825023
p_ni: 0.000001318
p_wrong: 0.000173659
Score: 0.177
Data Source: BioPlex,STRINGDB
PDXDC1
Family: Enzyme
Novelty: 0.16529476
p_int: 0.999818703
p_ni: 0.000181297
Data Source: BioPlex
UTP20
Novelty: 0.09170451
p_int: 0.999723741
p_ni: 0.000276259
Data Source: BioPlex
Publication Statistics
PubMed Score 268.87
PubMed score by year
PubTator Score 156.36
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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