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Tbio
RPL9
60S ribosomal protein L9

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295955
  • ENSP00000346022
  • ENSG00000163682
  • ENST00000449470
  • ENSP00000400467
  • ENST00000645496
  • ENSP00000494697

Symbol
  • L9
  • NPC-A-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
small molecule perturbation
1
kinase perturbation
0.98
histone modification site profile
0.8
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
13
10
18
8.1
98.8
alcohol use disorder measurement
5
5
2
7.9
97
mean corpuscular hemoglobin concentration
1
1
1
81.2
bitter alcoholic beverage consumption measurement
1
1
1
80.8
serum gamma-glutamyl transferase measurement
1
1
1
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
18
8.1
98.8
alcohol use disorder measurement
2
7.9
97
mean corpuscular hemoglobin concentration
1
81.2
bitter alcoholic beverage consumption measurement
1
80.8
serum gamma-glutamyl transferase measurement
1
75.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1298373
20005
Mouse
MGI:3642682
100042823
Dog
ribosomal protein L9
VGNC:53205
479109
Horse
ribosomal protein L9
VGNC:22533
100055158
Cow
ribosomal protein L9
282884
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Mouse
Dog
ribosomal protein L9
Horse
ribosomal protein L9
Cow
ribosomal protein L9
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32969-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (550)
1 – 10 of 550
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
p_int:  0.98779076
p_ni:  0.012209235
p_wrong:  6e-9
Score:  0.344
Data Source:  BioPlex,STRINGDB
CEP76
Tdark
Novelty:  0.3880387
p_int:  0.967489238
p_ni:  0.032510762
Score:  0.282
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.800823121
p_ni:  0.199176879
Score:  0.998
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.787925043
p_ni:  0.212074957
Score:  0.555
Data Source:  BioPlex,STRINGDB
EEF2
Tchem
Novelty:  0.00064095
Score:  0.999
Data Source:  STRINGDB
RPL36
Tbio
Novelty:  0.02259932
Score:  0.999
Data Source:  STRINGDB
RPL3L
Tbio
Novelty:  0.28678873
Score:  0.999
Data Source:  STRINGDB
RPS15
Tbio
Novelty:  0.00635155
Score:  0.999
Data Source:  STRINGDB
RPSA
Tbio
Novelty:  0.00250446
Score:  0.999
Data Source:  STRINGDB
RPL19
Tbio
Novelty:  0.00756385
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  112.48

PubMed score by year
PubTator Score  49.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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