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Tchem
CTH
Cystathionine gamma-lyase

Protein Classes
Protein Summary
Description
Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346806
  • ENSP00000311554
  • ENSG00000116761
  • ENST00000370938
  • ENSP00000359976
  • ENST00000411986
  • ENSP00000413407
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
transcription factor perturbation
0.96
PubMedID
0.91
small molecule perturbation
0.91
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.11   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.11   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Cysteine formation from homocysteine (R-HSA-1614603)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cysteine formation from homocysteine
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Name
Explore in Pharos
Explore in Source
Cysteine formation from homocysteine
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (159)
1 – 10 of 159
ZSCAN32
Tdark
Family: TF
Novelty: 3.83392226
p_int: 0.999917272
p_ni: 0.000082727
Score: 0.165
Data Source: BioPlex,STRINGDB
ARHGEF39
Tdark
Novelty: 0.30447134
p_int: 0.989956627
p_ni: 0.010021468
p_wrong: 0.000021906
Data Source: BioPlex
ZNF488
Tdark
Novelty: 0.41027707
p_int: 0.987812068
p_ni: 0.012187902
p_wrong: 3e-8
Score: 0.22
Data Source: BioPlex,STRINGDB
TMEM223
Tdark
Novelty: 0.89146194
p_int: 0.975978993
p_ni: 0.024009392
p_wrong: 0.000011615
Data Source: BioPlex
SLC25A32
Tbio
Family: Transporter
Novelty: 0.06270404
p_int: 0.973248102
p_ni: 0.026751892
p_wrong: 7e-9
Score: 0.379
Data Source: BioPlex,STRINGDB
FSD1
Tbio
Novelty: 0.03452477
p_int: 0.968658467
p_ni: 0.031341533
p_wrong: 1e-9
Data Source: BioPlex
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.959114556
p_ni: 0.040880182
p_wrong: 0.000005261
Data Source: BioPlex
GAPDHS
Tbio
Family: Enzyme
Novelty: 0.00885959
p_int: 0.944761949
p_ni: 0.055237956
p_wrong: 9.5e-8
Score: 0.347
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00437751
p_int: 0.934859136
p_ni: 0.065140847
p_wrong: 1.7e-8
Data Source: BioPlex
KLHL20
Tbio
Novelty: 0.12205871
p_int: 0.921961952
p_ni: 0.077990879
p_wrong: 0.000047169
Data Source: BioPlex
Publication Statistics
PubMed Score  507.11

PubMed score by year
PubTator Score  89.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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