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Tclin
CSF2RB
Cytokine receptor common subunit beta

Protein Summary
Description
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403662
  • ENSP00000384053
  • ENSG00000100368
  • ENST00000406230
  • ENSP00000385271

Symbol
  • IL3RB
  • IL5RB
  • CD131
  • IL3RB
  • IL5RB
  • SMDP5
  • CDw131
  • betaGMR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
PubMedID
0.92
disease perturbation
0.83
protein domain
0.73
biological term
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.49   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 656   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.49   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosquito bite reaction itch intensity measurement
1
1
1
55.9
eosinophil count
1
1
1
42.2
eosinophil percentage of leukocytes
1
1
1
42
Eczema
1
1
0
1
40.5
1
1
0
1
40.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosquito bite reaction itch intensity measurement
1
55.9
eosinophil count
1
42.2
eosinophil percentage of leukocytes
1
42
Eczema
0
1
40.5
0
1
40.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
colony stimulating factor 2 receptor beta common subunit
VGNC:6690
458802
Macaque
colony stimulating factor 2 receptor beta common subunit
697508
Mouse
MGI:1339760
12984
Rat
RGD:620189
171081
Dog
colony stimulating factor 2 receptor beta common subunit
VGNC:39656
481276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
colony stimulating factor 2 receptor beta common subunit
Macaque
colony stimulating factor 2 receptor beta common subunit
Mouse
Rat
Dog
colony stimulating factor 2 receptor beta common subunit
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (346)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Reactome
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Reactome
Disease
Reactome
Diseases associated with surfactant metabolism
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Disease
Diseases associated with surfactant metabolism
Protein-Protein Interactions (221)
1 – 10 of 221
CSF2RA
Tclin
Novelty: 0.00125121
Score: 0.997
Data Source: Reactome,STRINGDB
CSF2
Tbio
Novelty: 0.00010437
Score: 0.996
Data Source: Reactome,STRINGDB
IL5RA
Tclin
Novelty: 0.01418963
Score: 0.983
Data Source: Reactome,STRINGDB
IL3RA
Tclin
Novelty: 0.00216495
Score: 0.982
Data Source: Reactome,STRINGDB
IL3
Tbio
Novelty: 0.0002336
Score: 0.978
Data Source: Reactome,STRINGDB
IL5
Tclin
Novelty: 0.0001684
Score: 0.968
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.966
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.966
Data Source: Reactome,STRINGDB
IL2RB
Tclin
Novelty: 0.0050905
Score: 0.965
Data Source: STRINGDB
IL2RG
Tclin
Novelty: 0.00108272
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.49

PubMed score by year
PubTator Score  122.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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