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Tbio
DSG3
Desmoglein-3

Protein Summary
Description
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257189
  • ENSP00000257189
  • ENSG00000134757

Symbol
  • CDHF6
  • PVA
  • CDHF6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological term
0.71
virus perturbation
0.64
cellular component
0.63
gene perturbation
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.06   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 644   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.06   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
desmoglein 3
VGNC:5160
468511
Macaque
desmoglein 3
705685
Mouse
MGI:99499
13512
Rat
RGD:1592103
291752
Dog
desmoglein 3
VGNC:40107
403470
Species
Name
OMA
EggNOG
Inparanoid
Chimp
desmoglein 3
Macaque
desmoglein 3
Mouse
Rat
Dog
desmoglein 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32926-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Developmental Biology
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (81)
1 – 10 of 81
HSF2
Tbio
Family: TF
Novelty: 0.06458223
p_int: 0.999962372
p_ni: 0.000019666
p_wrong: 0.000017962
Data Source: BioPlex
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.999653791
p_ni: 0.000061192
p_wrong: 0.000285018
Score: 0.223
Data Source: BioPlex,STRINGDB
OAZ3
Tbio
Family: Enzyme
Novelty: 0.02374168
p_int: 0.858741311
p_ni: 0.00047611
p_wrong: 0.140782579
Score: 0.224
Data Source: BioPlex,STRINGDB
PKP3
Tbio
Novelty: 0.0269462
Score: 0.99
Data Source: STRINGDB
DSP
Tbio
Novelty: 0.00178018
Score: 0.989
Data Source: STRINGDB
PKP1
Tbio
Novelty: 0.0100609
Score: 0.989
Data Source: STRINGDB
PKP2
Tbio
Novelty: 0.00493803
Score: 0.985
Data Source: STRINGDB
JUP
Tbio
Novelty: 0.0081803
Score: 0.983
Data Source: STRINGDB
EVPL
Tbio
Novelty: 0.00274279
Score: 0.976
Data Source: STRINGDB
PPL
Tbio
Novelty: 0.00684645
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  555.06

PubMed score by year
PubTator Score  439.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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