Protein Summary
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
- ENST00000380205
- ENSP00000369553
- ENSG00000120242
- IFN-alphaB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.91 | ||
biological process | 0.82 | ||
tissue sample | 0.64 | ||
co-expressed gene | 0.57 | ||
gene perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.62 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.62 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
IFNA4
Novelty: 0.04421984
p_int: 0.999997594
p_wrong: 0.000002406
Score: 0.982
Data Source: BioPlex,STRINGDB
UBR3
Family: Enzyme
Novelty: 0.14930754
p_int: 0.999969167
p_ni: 0.000030833
Data Source: BioPlex
ISG15
Novelty: 0.00203781
p_int: 0.999626893
p_ni: 0.000013606
p_wrong: 0.000359501
Score: 0.802
Data Source: BioPlex,STRINGDB
OMA1
Family: Enzyme
Novelty: 0.00963387
p_int: 0.999501136
p_ni: 0.000498864
Score: 0.303
Data Source: BioPlex,STRINGDB
IFIT1
Novelty: 0.00562299
p_int: 0.999497627
p_ni: 0.000502371
p_wrong: 3e-9
Score: 0.303
Data Source: BioPlex,STRINGDB
IFIT3
Novelty: 0.00568113
p_int: 0.995248987
p_ni: 0.000845282
p_wrong: 0.003905731
Score: 0.228
Data Source: BioPlex,STRINGDB
APOE
Novelty: 0.00005049
p_int: 0.986406432
p_ni: 0.013288104
p_wrong: 0.000305464
Score: 0.216
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Upstream (1)
Downstream (17)
1 – 1 of 1
Pathways (70)
Reactome (10)
KEGG (22)
PathwayCommons (12)
WikiPathways (26)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Factors involved in megakaryocyte development and platelet production | ||||
Hemostasis | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (3)
Components (2)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 1 | 2 | 11.7 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 11.3 | |||||
1 | 1 | 0 | 10.7 | 7.8 | |||||
maculopapular eruption | 1 | 1 | 0 | 10.7 | 7.8 | ||||
response to lamotrigine | 1 | 1 | 0 | 10.7 | 7.8 | ||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil count | 2 | 11.7 | |||||
lymphocyte percentage of leukocytes | 1 | 11.3 | |||||
0 | 10.7 | 7.8 | |||||
maculopapular eruption | 0 | 10.7 | 7.8 | ||||
response to lamotrigine | 0 | 10.7 | 7.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | interferon alpha 8 | 709755 | ||||||
Mouse | MGI:107664 | 15967 | ||||||
Rat | RGD:1306334 | 298205 | ||||||
Horse | interferon, alpha 1 | 100053022 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | interferon alpha 8 | |||||
Mouse | ||||||
Rat | ||||||
Horse | interferon, alpha 1 | |||||
Publication Statistics
PubMed Score 27.62
PubMed score by year
PubTator Score 76.05
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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