Tbio IFNA8 Interferon alpha-8

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Uniprot Accession IDs

• P32881
• P01565
• P09236
• Q5VWV7
• Q5VYQ3
• IFN-alpha-8

Gene Name

• IFNA8

Ensembl ID

• ENST00000380205
• ENSP00000369553
• ENSG00000120242

Symbol

• IFN-alphaB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.91
biological process	0.82
tissue sample	0.64
co-expressed gene	0.57
gene perturbation	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.62   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.62   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

IFNA4

Tbio

Novelty:  0.04421984

p_int:  0.999997594

p_wrong:  0.000002406

Score:  0.982

Data Source:  BioPlex,STRINGDB

UBR3

Tbio

Family:  Enzyme

Novelty:  0.14930754

p_int:  0.999969167

p_ni:  0.000030833

Data Source:  BioPlex

ISG15

Tbio

Novelty:  0.00203781

p_int:  0.999626893

p_ni:  0.000013606

p_wrong:  0.000359501

Score:  0.802

Data Source:  BioPlex,STRINGDB

OMA1

Tbio

Family:  Enzyme

Novelty:  0.00963387

p_int:  0.999501136

p_ni:  0.000498864

Score:  0.303

Data Source:  BioPlex,STRINGDB

IFIT1

Tbio

Novelty:  0.00562299

p_int:  0.999497627

p_ni:  0.000502371

p_wrong:  3e-9

Score:  0.303

Data Source:  BioPlex,STRINGDB

IFIT3

Tbio

Novelty:  0.00568113

p_int:  0.995248987

p_ni:  0.000845282

p_wrong:  0.003905731

Score:  0.228

Data Source:  BioPlex,STRINGDB

APOE

Tbio

Novelty:  0.00005049

p_int:  0.986406432

p_ni:  0.013288104

p_wrong:  0.000305464

Score:  0.216

Data Source:  BioPlex,STRINGDB

IFNA1

Tbio

Novelty:  0.0000962

p_int:  0.980803479

p_ni:  0.019196511

p_wrong:  1e-8

Data Source:  BioPlex

IFNAR1

Tclin

Novelty:  0.00175488

Score:  0.96

Data Source:  STRINGDB

IFNAR2

Tclin

Novelty:  0.00453303

Score:  0.939

Data Source:  STRINGDB

Nearest Tclin Targets (18)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (17)

1 – 1 of 1

TLR9

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  4

1: Toll-like receptor signaling pathway

2: Tuberculosis

3: Measles

4: Herpes simplex virus 1 infection

Pathways (70)

Reactome (10)

KEGG (22)

PathwayCommons (12)

WikiPathways (26)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (3)

Components (2)

Processes (12)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
type I interferon receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytokine receptor binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	1	2		11.7
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		11.3
epilepsy	EFO_0000474	1	1	0	10.7	7.8
maculopapular eruption	EFO_1001253	1	1	0	10.7	7.8
response to lamotrigine	EFO_0007661	1	1	0	10.7	7.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		11.7
lymphocyte percentage of leukocytes	EFO_0007993	1		11.3
epilepsy	EFO_0000474	0	10.7	7.8
maculopapular eruption	EFO_1001253	0	10.7	7.8
response to lamotrigine	EFO_0007661	0	10.7	7.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Antiviral defense
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
epilepsy
lymphocyte percentage of leukocytes
maculopapular eruption
neutrophil count
neutrophil percentage of leukocytes
response to lamotrigine

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	interferon alpha 8		709755
Mouse	interferon alpha 4	MGI:107664	15967
Rat	interferon, alpha 4	RGD:1306334	298205
Horse	interferon, alpha 1		100053022

Species	Name	OMA	EggNOG	Inparanoid
Macaque	interferon alpha 8
Mouse	interferon alpha 4
Rat	interferon, alpha 4
Horse	interferon, alpha 1

Publication Statistics

PubMed Score 27.62

PubMed score by year

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PubTator Score 76.05

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (8)

Items per page:

10

0 of 0

PMID	Year	Title