Tbio IFNA8 Interferon alpha-8

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Uniprot Accession IDs

• P32881
• P01565
• P09236
• Q5VWV7
• Q5VYQ3
• IFN-alpha-8

Gene Name

• IFNA8

Ensembl ID

• ENST00000380205
• ENSP00000369553
• ENSG00000120242

Symbol

• IFN-alphaB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.91
biological process	0.82
tissue sample	0.64
co-expressed gene	0.57
gene perturbation	0.54

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.52   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.52   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (70)

Reactome (10)

KEGG (22)

PathwayCommons (12)

WikiPathways (26)

Cytokine Signaling in Immune system (R-HSA-1280215)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (17)

Functions (3)

Components (2)

Processes (12)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
type I interferon receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytokine receptor binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

IFNA4

Tbio

Novelty: 0.04421984

p_int: 0.999997594

p_wrong: 0.000002406

Score: 0.982

Data Source: BioPlex,STRINGDB

UBR3

Tbio

Family: Enzyme

Novelty: 0.14930754

p_int: 0.999969167

p_ni: 0.000030833

Data Source: BioPlex

ISG15

Tbio

Novelty: 0.00203781

p_int: 0.999626893

p_ni: 0.000013606

p_wrong: 0.000359501

Score: 0.802

Data Source: BioPlex,STRINGDB

OMA1

Tbio

Family: Enzyme

Novelty: 0.00963387

p_int: 0.999501136

p_ni: 0.000498864

Score: 0.303

Data Source: BioPlex,STRINGDB

IFIT1

Tbio

Novelty: 0.00562299

p_int: 0.999497627

p_ni: 0.000502371

p_wrong: 3e-9

Score: 0.303

Data Source: BioPlex,STRINGDB

IFIT3

Tbio

Novelty: 0.00568113

p_int: 0.995248987

p_ni: 0.000845282

p_wrong: 0.003905731

Score: 0.228

Data Source: BioPlex,STRINGDB

APOE

Tbio

Novelty: 0.00005049

p_int: 0.986406432

p_ni: 0.013288104

p_wrong: 0.000305464

Score: 0.216

Data Source: BioPlex,STRINGDB

IFNA1

Tbio

Novelty: 0.0000962

p_int: 0.980803479

p_ni: 0.019196511

p_wrong: 1e-8

Data Source: BioPlex

IFNAR1

Tclin

Novelty: 0.00175488

Score: 0.96

Data Source: STRINGDB

IFNAR2

Tclin

Novelty: 0.00453303

Score: 0.939

Data Source: STRINGDB

Publication Statistics

PubMed Score  27.52

PubMed score by year

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PubTator Score  76.05

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Antiviral defense
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Polymorphism
Reference proteome
Secreted
Signal