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Tbio
IFNA8
Interferon alpha-8

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380205
  • ENSP00000369553
  • ENSG00000120242

Symbol
  • IFN-alphaB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.91
biological process
0.82
tissue sample
0.64
co-expressed gene
0.57
gene perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.52   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.52   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (70)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (83)
1 – 10 of 83
IFNA4
Tbio
Novelty: 0.04421984
p_int: 0.999997594
p_wrong: 0.000002406
Score: 0.982
Data Source: BioPlex,STRINGDB
UBR3
Tbio
Family: Enzyme
Novelty: 0.14930754
p_int: 0.999969167
p_ni: 0.000030833
Data Source: BioPlex
ISG15
Tbio
Novelty: 0.00203781
p_int: 0.999626893
p_ni: 0.000013606
p_wrong: 0.000359501
Score: 0.802
Data Source: BioPlex,STRINGDB
OMA1
Tbio
Family: Enzyme
Novelty: 0.00963387
p_int: 0.999501136
p_ni: 0.000498864
Score: 0.303
Data Source: BioPlex,STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
p_int: 0.999497627
p_ni: 0.000502371
p_wrong: 3e-9
Score: 0.303
Data Source: BioPlex,STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
p_int: 0.995248987
p_ni: 0.000845282
p_wrong: 0.003905731
Score: 0.228
Data Source: BioPlex,STRINGDB
APOE
Tbio
Novelty: 0.00005049
p_int: 0.986406432
p_ni: 0.013288104
p_wrong: 0.000305464
Score: 0.216
Data Source: BioPlex,STRINGDB
IFNA1
Tbio
Novelty: 0.0000962
p_int: 0.980803479
p_ni: 0.019196511
p_wrong: 1e-8
Data Source: BioPlex
IFNAR1
Tclin
Novelty: 0.00175488
Score: 0.96
Data Source: STRINGDB
IFNAR2
Tclin
Novelty: 0.00453303
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.52

PubMed score by year
PubTator Score  76.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer