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Tbio
IFNA8
Interferon alpha-8

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380205
  • ENSP00000369553
  • ENSG00000120242

Symbol
  • IFN-alphaB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.91
biological process
0.82
tissue sample
0.64
co-expressed gene
0.57
gene perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.62   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.62   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
IFNA4
Tbio
Novelty:  0.04421984
p_int:  0.999997594
p_wrong:  0.000002406
Score:  0.982
Data Source:  BioPlex,STRINGDB
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.999969167
p_ni:  0.000030833
Data Source:  BioPlex
ISG15
Tbio
Novelty:  0.00203781
p_int:  0.999626893
p_ni:  0.000013606
p_wrong:  0.000359501
Score:  0.802
Data Source:  BioPlex,STRINGDB
OMA1
Tbio
Family:  Enzyme
Novelty:  0.00963387
p_int:  0.999501136
p_ni:  0.000498864
Score:  0.303
Data Source:  BioPlex,STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
p_int:  0.999497627
p_ni:  0.000502371
p_wrong:  3e-9
Score:  0.303
Data Source:  BioPlex,STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
p_int:  0.995248987
p_ni:  0.000845282
p_wrong:  0.003905731
Score:  0.228
Data Source:  BioPlex,STRINGDB
APOE
Tbio
Novelty:  0.00005049
p_int:  0.986406432
p_ni:  0.013288104
p_wrong:  0.000305464
Score:  0.216
Data Source:  BioPlex,STRINGDB
IFNA1
Tbio
Novelty:  0.0000962
p_int:  0.980803479
p_ni:  0.019196511
p_wrong:  1e-8
Data Source:  BioPlex
IFNAR1
Tclin
Novelty:  0.00175488
Score:  0.96
Data Source:  STRINGDB
IFNAR2
Tclin
Novelty:  0.00453303
Score:  0.939
Data Source:  STRINGDB
Pathways (70)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
11.7
lymphocyte percentage of leukocytes
1
1
1
11.3
1
1
0
10.7
7.8
maculopapular eruption
1
1
0
10.7
7.8
response to lamotrigine
1
1
0
10.7
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
11.7
lymphocyte percentage of leukocytes
1
11.3
0
10.7
7.8
maculopapular eruption
0
10.7
7.8
response to lamotrigine
0
10.7
7.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interferon alpha 8
709755
Mouse
MGI:107664
15967
Rat
RGD:1306334
298205
Horse
interferon, alpha 1
100053022
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interferon alpha 8
Mouse
Rat
Horse
interferon, alpha 1
Publication Statistics
PubMed Score 27.62
PubMed score by year
PubTator Score 76.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title