Protein Summary
Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000261653
- ENSP00000261653
- ENSG00000111450
- ENST00000392373
- ENSP00000376178
- EPIM
- STX2A
- STX2B
- STX2C
- EPM
- EPIM
- STX2A
- STX2B
- STX2C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.98 | ||
histone modification site profile | 0.82 | ||
protein domain | 0.73 | ||
cellular component | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1663.86 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 248 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1663.86 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 248 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0