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Tbio
GTF2H1
General transcription factor IIH subunit 1

Protein Summary
Description
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265963
  • ENSP00000265963
  • ENSG00000110768
  • ENST00000453096
  • ENSP00000393638
  • ENST00000534641
  • ENSP00000435375

Symbol
  • BTF2
  • P62
  • BTF2
  • TFB1
  • TFIIH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
histone modification site profile
0.87
transcription factor binding site profile
0.85
disease perturbation
0.83
microRNA
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.01   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.01   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum amyloid A protein measurement
1
1
1
90.5
blood metabolite measurement
1
1
1
84.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum amyloid A protein measurement
1
90.5
blood metabolite measurement
1
84.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIH subunit 1
VGNC:3118
748842
Macaque
general transcription factor IIH subunit 1
694564
Mouse
MGI:1277216
14884
Rat
RGD:1308225
361580
Dog
general transcription factor IIH subunit 1
VGNC:41547
476881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIH subunit 1
Macaque
general transcription factor IIH subunit 1
Mouse
Rat
Dog
general transcription factor IIH subunit 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32780-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Disease
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
DNA Repair
Disease
Dual Incision in GG-NER
Dual incision in TC-NER
Epigenetic regulation of gene expression
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (251)
1 – 10 of 251
GTF2H4
Tbio
Novelty: 0.03140561
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
ERCC3
Tbio
Family: Enzyme
Novelty: 0.00978601
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
GTF2H3
Tbio
Novelty: 0.08168167
p_int: 0.999999983
p_ni: 1.6e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
GTF2H5
Tbio
Novelty: 0.03493285
p_int: 0.999999967
p_ni: 3.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
FGL1
Tbio
Novelty: 0.02650803
p_int: 0.999943182
p_ni: 0.000056818
Data Source: BioPlex
LZTS2
Tbio
Novelty: 0.09515452
p_int: 0.767812275
p_ni: 0.230324412
p_wrong: 0.001863313
Data Source: BioPlex
ERCC2
Tbio
Family: Enzyme
Novelty: 0.00240155
Score: 0.999
Data Source: STRINGDB
GTF2H2C
Tdark
Novelty: 1.59026944
Score: 0.999
Data Source: STRINGDB
GTF2H2
Tbio
Novelty: 0.02761619
Score: 0.999
Data Source: STRINGDB
CDK7
Tchem
Family: Kinase
Novelty: 0.00322814
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.01

PubMed score by year
PubTator Score  20.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer