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Tclin
HPD
4-hydroxyphenylpyruvate dioxygenase

Protein Summary
Description
Key enzyme in the degradation of tyrosine. The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000543163
  • ENSP00000441677
  • ENSG00000158104

Symbol
  • PPD
  • PPD
  • 4HPPD
  • GLOD3
  • 4-HPPD
  • HPPDASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
disease perturbation
0.87
transcription factor binding site profile
0.72
cellular component
0.61
tissue
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.98   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.98   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 109
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nitisinone
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GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
11
6
15
99.6
platelet crit
2
2
4
95.8
platelet count
3
2
2
3.9
95.4
reticulocyte measurement
3
2
3
86.4
blood metabolite measurement
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
15
99.6
platelet crit
4
95.8
platelet count
2
3.9
95.4
reticulocyte measurement
3
86.4
blood metabolite measurement
1
70.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
4-hydroxyphenylpyruvate dioxygenase
VGNC:5422
473296
Macaque
4-hydroxyphenylpyruvate dioxygenase
700940
Mouse
MGI:96213
15445
Rat
RGD:61974
29531
Dog
4-hydroxyphenylpyruvate dioxygenase
VGNC:41770
610778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
4-hydroxyphenylpyruvate dioxygenase
Macaque
4-hydroxyphenylpyruvate dioxygenase
Mouse
Rat
Dog
4-hydroxyphenylpyruvate dioxygenase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32754-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (119)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Phenylalanine and tyrosine metabolism
Reactome
Tyrosine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Phenylalanine and tyrosine metabolism
Tyrosine catabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
RBMX
Tbio
Novelty:  0.01705784
p_int:  0.999997097
p_ni:  0.000002903
Score:  0.202
Data Source:  BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.918611519
p_ni:  0.081384785
p_wrong:  0.000003696
Score:  0.547
Data Source:  BioPlex,STRINGDB
HGD
Tbio
Family:  Enzyme
Novelty:  0.01924565
Score:  0.998
Data Source:  STRINGDB
TAT
Tbio
Family:  Enzyme
Novelty:  0.00079176
Score:  0.994
Data Source:  STRINGDB
FAH
Tbio
Family:  Enzyme
Novelty:  0.00456617
Score:  0.978
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.928
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.927
Data Source:  STRINGDB
IL4I1
Tbio
Family:  Enzyme
Novelty:  0.00414355
Score:  0.91
Data Source:  STRINGDB
SYCN
Tbio
Novelty:  0.0354405
Score:  0.903
Data Source:  STRINGDB
MIF
Tchem
Novelty:  0.00056843
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  200.98

PubMed score by year
PubTator Score  116.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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