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Tclin
SSTR3
Somatostatin receptor type 3

Protein Summary
Description
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610913
  • ENSP00000480971
  • ENSG00000278195
  • ENST00000617123
  • ENSP00000481325

Symbol
  • SS3R
  • SS3-R
  • SS-3-R
  • SSR-28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.99
virus perturbation
0.76
biological process
0.71
cellular component
0.66
cell type or tissue
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.58   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.58   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 226
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
somatostatin receptor 3
696585
Mouse
MGI:98329
20607
Rat
RGD:620308
171044
Dog
somatostatin receptor 3
VGNC:46845
481272
Horse
somatostatin receptor 3
VGNC:23622
100069706
Species
Name
OMA
EggNOG
Inparanoid
Macaque
somatostatin receptor 3
Mouse
Rat
Dog
somatostatin receptor 3
Horse
somatostatin receptor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P32745-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Protein-Protein Interactions (302)
1 – 10 of 302
SST
Tbio
Novelty: 0.00005944
Score: 0.995
Data Source: STRINGDB
CORT
Tbio
Novelty: 0.00789975
Score: 0.968
Data Source: STRINGDB
TAS2R4
Tbio
Family: GPCR
Novelty: 0.02938385
Score: 0.964
Data Source: STRINGDB
BBS2
Tbio
Novelty: 0.00835161
Score: 0.96
Data Source: STRINGDB
BBS4
Tbio
Novelty: 0.01825873
Score: 0.96
Data Source: STRINGDB
BBS1
Tbio
Novelty: 0.00939439
Score: 0.958
Data Source: STRINGDB
TAS2R1
Tbio
Family: GPCR
Novelty: 0.04676914
Score: 0.955
Data Source: STRINGDB
BBS7
Tbio
Novelty: 0.03611111
Score: 0.955
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.954
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  97.58

PubMed score by year
PubTator Score  100.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer