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Tbio
GBP2
Guanylate-binding protein 2

Protein Summary
Description
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370466
  • ENSP00000359497
  • ENSG00000162645
  • ENST00000464839
  • ENSP00000434282
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
gene perturbation
0.98
PubMedID
0.98
molecular function
0.91
small molecule perturbation
0.87


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.38   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.38   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate binding protein 2
VGNC:6830
457003
Opossum
guanylate-binding protein 1-like
100027633
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate binding protein 2
Opossum
guanylate-binding protein 1-like
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Interferon gamma signaling
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (213)
1 – 10 of 213
GBP3
Tbio
Novelty: 0.06761345
p_int: 0.999999999
p_ni: 1e-9
Score: 0.876
Data Source: BioPlex,STRINGDB
GBP7
Tbio
Novelty: 0.17145268
p_int: 0.999999878
p_ni: 8.5e-8
p_wrong: 3.7e-8
Score: 0.345
Data Source: BioPlex,STRINGDB
GBP1
Tbio
Novelty: 0.00634662
p_int: 0.999999388
p_ni: 6.12e-7
Score: 0.937
Data Source: BioPlex,STRINGDB
ADD3
Tbio
Family: Enzyme
Novelty: 0.02164464
p_int: 0.999998765
p_ni: 0.000001235
Score: 0.189
Data Source: BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int: 0.999996719
p_ni: 0.000002044
p_wrong: 0.000001237
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999961169
p_ni: 0.00003883
p_wrong: 1e-9
Data Source: BioPlex
ADD1
Tbio
Family: Enzyme
Novelty: 0.0040587
p_int: 0.998231431
p_ni: 0.001768569
Score: 0.199
Data Source: BioPlex,STRINGDB
STMN1
Tbio
Novelty: 0.00117369
p_int: 0.960143208
p_ni: 0.037345987
p_wrong: 0.002510805
Data Source: BioPlex
HSP90AB1
Tchem
Novelty: 0.00907961
p_int: 0.948611942
p_ni: 0.051388058
Score: 0.183
Data Source: BioPlex,STRINGDB
PCBP3
Tbio
Novelty: 0.11681812
p_int: 0.942807247
p_ni: 0.051347006
p_wrong: 0.005845747
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  56.38

PubMed score by year
PubTator Score  23.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer