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Tbio
GBP1
Guanylate-binding protein 1

Protein Summary
Description
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370473
  • ENSP00000359504
  • ENSG00000117228
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
virus perturbation
1
molecular function
0.93
transcription factor perturbation
0.8
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.78   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.78   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (222)
1 – 10 of 222
GBP3
Tbio
Novelty:  0.06761345
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.893
Data Source:  BioPlex,STRINGDB
GBP5
Tbio
Novelty:  0.03705719
p_int:  0.999999834
p_ni:  1.22e-7
p_wrong:  4.4e-8
Score:  0.826
Data Source:  BioPlex,STRINGDB
GBP2
Tbio
Novelty:  0.01803054
p_int:  0.999999388
p_ni:  6.12e-7
Score:  0.937
Data Source:  BioPlex,STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
p_int:  0.999302822
p_ni:  0.000697103
p_wrong:  7.5e-8
Score:  0.284
Data Source:  BioPlex,STRINGDB
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.993644635
p_ni:  0.006336536
p_wrong:  0.000018828
Score:  0.193
Data Source:  BioPlex,STRINGDB
AFM
Tbio
Novelty:  0.00607207
p_int:  0.993644635
p_ni:  0.006336536
p_wrong:  0.000018828
Score:  0.192
Data Source:  BioPlex,STRINGDB
UTP6
Tbio
Novelty:  0.06525007
p_int:  0.976820485
p_ni:  0.023146135
p_wrong:  0.00003338
Score:  0.207
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.80010322
p_ni:  0.199896686
p_wrong:  9.4e-8
Data Source:  BioPlex
TRIM22
Tbio
Family:  Enzyme
Novelty:  0.0221032
Score:  0.978
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.974
Data Source:  STRINGDB
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (32)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
1
49.5
blood urea nitrogen measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
49.5
blood urea nitrogen measurement
1
21.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate binding protein 1
VGNC:6829
738075
Macaque
guanylate binding protein 2
694684
Mouse
MGI:95666
14468
Rat
RGD:1311877
304266
Dog
guanylate binding protein 1
490172
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate binding protein 1
Macaque
guanylate binding protein 2
Mouse
Rat
Dog
guanylate binding protein 1
Publication Statistics
PubMed Score 190.78
PubMed score by year
PubTator Score 100.06
PubTator score by year