PYCR1
Pyrroline-5-carboxylate reductase 1, mitochondrial
Protein Summary
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
- ENST00000329875
- ENSP00000328858
- ENSG00000183010
- ENST00000337943
- ENSP00000336579
- ENST00000402252
- ENSP00000384949
- ENST00000619204
- ENSP00000479793
- P5C
- P5CR
- PRO3
- PYCR
- PIG45
- PP222
- ARCL2B
- ARCL3B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.83 | ||
histone modification site profile | 0.83 | ||
kinase perturbation | 0.76 | ||
hub protein | 0.75 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 577.49 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 577.49 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0