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Tbio
PYCR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

Protein Summary
Description
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329875
  • ENSP00000328858
  • ENSG00000183010
  • ENST00000337943
  • ENSP00000336579
  • ENST00000402252
  • ENSP00000384949
  • ENST00000619204
  • ENSP00000479793

Symbol
  • P5C
  • P5CR
  • PRO3
  • PYCR
  • PIG45
  • PP222
  • ARCL2B
  • ARCL3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
histone modification site profile
0.83
kinase perturbation
0.76
hub protein
0.75
disease perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 427.93   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 427.93   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyrroline-5-carboxylate reductase 1
VGNC:12621
454977
Macaque
pyrroline-5-carboxylate reductase 1
715182
Mouse
MGI:2384795
209027
Rat
RGD:1307863
287877
Dog
pyrroline-5-carboxylate reductase 1
VGNC:45223
483372
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyrroline-5-carboxylate reductase 1
Macaque
pyrroline-5-carboxylate reductase 1
Mouse
Rat
Dog
pyrroline-5-carboxylate reductase 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32322-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Glutamate and glutamine metabolism (R-HSA-8964539)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glutamate and glutamine metabolism
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (98)
1 – 10 of 98
PYCR2
Tbio
Family: Enzyme
Novelty: 0.05660996
p_int: 0.999999898
p_ni: 1.02e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
KLHDC10
Tdark
Novelty: 0.40978227
p_int: 0.999990057
p_ni: 0.000009788
p_wrong: 1.55e-7
Score: 0.532
Data Source: BioPlex,STRINGDB
NUDT5
Tbio
Family: Enzyme
Novelty: 0.02550535
p_int: 0.999714432
p_ni: 0.000285568
Score: 0.94
Data Source: BioPlex,STRINGDB
PYCR3
Tbio
Family: Enzyme
Novelty: 0.1041757
p_int: 0.925693268
p_ni: 0.074306732
Score: 0.987
Data Source: BioPlex,STRINGDB
ALDH4A1
Tbio
Family: Enzyme
Novelty: 0.01316227
Score: 0.979
Data Source: STRINGDB
ALDH18A1
Tbio
Family: Enzyme
Novelty: 0.00301673
Score: 0.973
Data Source: STRINGDB
PRODH2
Tbio
Family: Enzyme
Novelty: 0.09377289
Score: 0.949
Data Source: STRINGDB
PIPOX
Tbio
Family: Enzyme
Novelty: 0.04107707
Score: 0.916
Data Source: STRINGDB
LAP3
Tchem
Family: Enzyme
Novelty: 0.00327467
Score: 0.911
Data Source: STRINGDB
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  427.93

PubMed score by year
PubTator Score  212.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer