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Tbio
DCTD
Deoxycytidylate deaminase

Protein Summary
Description
Supplies the nucleotide substrate for thymidylate synthetase. The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357067
  • ENSP00000349576
  • ENSG00000129187
  • ENST00000438320
  • ENSP00000398194
  • ENST00000510370
  • ENSP00000424017
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor binding site profile
0.79
disease perturbation
0.74
transcription factor perturbation
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.15   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.15   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
65.9
mathematical ability
1
1
1
5.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
65.9
mathematical ability
1
5.5
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dCMP deaminase
VGNC:10854
461620
Macaque
dCMP deaminase
700995
Mouse
MGI:2444529
320685
Rat
RGD:1359671
290741
Dog
dCMP deaminase
VGNC:39815
607328
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dCMP deaminase
Macaque
dCMP deaminase
Mouse
Rat
Dog
dCMP deaminase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32321-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (67)
1 – 10 of 67
TYMS
Tclin
Family:  Enzyme
Novelty:  0.00087522
Score:  0.993
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.98
Data Source:  STRINGDB
DUT
Tchem
Family:  Enzyme
Novelty:  0.0026993
Score:  0.978
Data Source:  STRINGDB
DTYMK
Tbio
Family:  Kinase
Novelty:  0.00746576
Score:  0.976
Data Source:  STRINGDB
TK1
Tchem
Family:  Kinase
Novelty:  0.00139343
Score:  0.967
Data Source:  STRINGDB
DCTPP1
Tchem
Family:  Enzyme
Novelty:  0.05521767
Score:  0.965
Data Source:  STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
Score:  0.954
Data Source:  STRINGDB
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
Score:  0.942
Data Source:  STRINGDB
TK2
Tchem
Family:  Kinase
Novelty:  0.10642442
Score:  0.931
Data Source:  STRINGDB
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
Score:  0.923
Data Source:  STRINGDB
Publication Statistics
PubMed Score  39.15

PubMed score by year
PubTator Score  75.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer