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Tchem
CDA
Cytidine deaminase

Protein Summary
Description
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375071
  • ENSP00000364212
  • ENSG00000158825

Symbol
  • CDD
  • CDD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
PubMedID
0.8
molecular function
0.76
biological process
0.75
disease
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.29   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.29   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
67.3
mean reticulocyte volume
1
1
1
56.5
alkaline phosphatase measurement
1
1
1
55.9
mean corpuscular volume
1
1
1
55.4
apolipoprotein A 1 measurement
1
1
1
51.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
67.3
mean reticulocyte volume
1
56.5
alkaline phosphatase measurement
1
55.9
mean corpuscular volume
1
55.4
apolipoprotein A 1 measurement
1
51.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of nucleotides
Neutrophil degranulation
Protein-Protein Interactions (202)
1 – 10 of 202
MPP2
Tbio
Novelty: 0.0372293
p_int: 0.999999553
p_ni: 4.47e-7
Score: 0.714
Data Source: BioPlex,STRINGDB
MTMR9
Tbio
Novelty: 0.09702778
p_int: 0.999845015
p_ni: 0.000154566
p_wrong: 4.19e-7
Score: 0.747
Data Source: BioPlex,STRINGDB
MPP6
Tbio
Novelty: 0.08883057
p_int: 0.999773731
p_ni: 0.000226269
Score: 0.592
Data Source: BioPlex,STRINGDB
CDKN2C
Tbio
Family: Enzyme
Novelty: 0.00806886
p_int: 0.998779624
p_ni: 0.001214276
p_wrong: 0.0000061
Score: 0.638
Data Source: BioPlex,STRINGDB
APBA3
Tbio
Novelty: 0.05059532
p_int: 0.995763469
p_ni: 0.00423653
p_wrong: 1e-9
Score: 0.191
Data Source: BioPlex,STRINGDB
LIN7A
Tbio
Novelty: 0.0202389
p_int: 0.994045364
p_ni: 0.005954604
p_wrong: 3.3e-8
Score: 0.818
Data Source: BioPlex,STRINGDB
MTMR6
Tbio
Family: Enzyme
Novelty: 0.13067072
p_int: 0.993867425
p_ni: 0.006132531
p_wrong: 4.4e-8
Score: 0.552
Data Source: BioPlex,STRINGDB
RNF181
Tbio
Family: Enzyme
Novelty: 0.27482636
p_int: 0.94990942
p_ni: 0.029917178
p_wrong: 0.020173402
Score: 0.19
Data Source: BioPlex,STRINGDB
ZMYM6
Tdark
Novelty: 0.4933879
p_int: 0.922030742
p_ni: 0.077969258
Data Source: BioPlex
PYM1
Tbio
Novelty: 0.04117785
p_int: 0.873968073
p_ni: 0.126031815
p_wrong: 1.12e-7
Score: 0.588
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  267.29

PubMed score by year
PubTator Score  1055.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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