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Tbio
FOXN2
Forkhead box protein N2

Protein Summary
Description
Binds to the purine-rich region in HTLV-I LTR. This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340553
  • ENSP00000343633
  • ENSG00000170802

Symbol
  • HTLF
  • HTLF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
microRNA
0.83
small molecule perturbation
0.78
virus perturbation
0.72
histone modification site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
RFX1
Tbio
Family:  TF
Novelty:  0.00225236
p_int:  0.999999373
p_ni:  6.27e-7
Score:  0.304
Data Source:  BioPlex,STRINGDB
RFX2
Tbio
Family:  TF
Novelty:  0.04660141
p_int:  0.999998958
p_ni:  8.79e-7
p_wrong:  1.62e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.998748759
p_ni:  0.001251237
p_wrong:  5e-9
Score:  0.321
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.970476342
p_ni:  0.029523657
p_wrong:  1e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
SHPRH
Tbio
Family:  Epigenetic
Novelty:  0.04914227
Score:  0.731
Data Source:  STRINGDB
ETS1
Tbio
Family:  TF
Novelty:  0.00105233
Score:  0.684
Data Source:  STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
Score:  0.665
Data Source:  STRINGDB
GLI3
Tbio
Family:  TF
Novelty:  0.00051217
Score:  0.649
Data Source:  STRINGDB
HLTF
Tbio
Family:  Enzyme
Novelty:  0.01177896
Score:  0.639
Data Source:  STRINGDB
HOXC13
Tbio
Family:  TF
Novelty:  0.01749797
Score:  0.628
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
79.8
sex hormone-binding globulin measurement
3
1
3
62.8
reticulocyte count
3
3
3
59.5
reticulocyte measurement
2
2
2
54.3
mathematical ability
3
2
3
43.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
79.8
sex hormone-binding globulin measurement
3
62.8
reticulocyte count
3
59.5
reticulocyte measurement
2
54.3
mathematical ability
3
43.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box N2
VGNC:256
459220
Macaque
forkhead box N2
715878
Mouse
MGI:1347478
14236
Rat
RGD:1562291
301676
Dog
forkhead box N2
VGNC:40961
100856358
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box N2
Macaque
forkhead box N2
Mouse
Rat
Dog
forkhead box N2
Publication Statistics
PubMed Score 16.68
PubMed score by year
PubTator Score 6.61
PubTator score by year
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Related Publications
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PMID
Year
Title