You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
GRK4
G protein-coupled receptor kinase 4

Protein Summary
Description
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345167
  • ENSP00000264764
  • ENSG00000125388
  • ENST00000398051
  • ENSP00000381128
  • ENST00000398052
  • ENSP00000381129
  • ENST00000504933
  • ENSP00000427445

Symbol
  • GPRK2L
  • GPRK4
  • IT11
  • GPRK4
  • GRK4a
  • GPRK2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.93
histone modification site profile
0.88
transcription factor binding site profile
0.87
tissue
0.64


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.52   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.52   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
2
2
2
72.6
household income
1
2
2
30
mean platelet volume
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
2
72.6
household income
2
30
mean platelet volume
1
13.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor kinase 4
VGNC:2985
461082
Mouse
MGI:95801
14772
Rat
RGD:61858
59077
Dog
G protein-coupled receptor kinase 4
VGNC:41504
479075
Horse
G protein-coupled receptor kinase 4
VGNC:18596
100053624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor kinase 4
Mouse
Rat
Dog
G protein-coupled receptor kinase 4
Horse
G protein-coupled receptor kinase 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32298-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (67)
1 – 10 of 67
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.925
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.924
Data Source: STRINGDB
ARRB2
Tbio
Novelty: 0.00148149
Score: 0.918
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.912
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.912
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.912
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.912
Data Source: STRINGDB
ARRB1
Tbio
Novelty: 0.00262758
Score: 0.893
Data Source: STRINGDB
OPRM1
Tclin
Family: GPCR
Novelty: 0.0003701
Score: 0.862
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.769
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.52

PubMed score by year
PubTator Score  88.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer