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Tclin
CHRNA3
Neuronal acetylcholine receptor subunit alpha-3

Protein Classes
Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326828
  • ENSP00000315602
  • ENSG00000080644
  • ENST00000348639
  • ENSP00000267951
  • ENST00000559658
  • ENSP00000452896

Symbol
  • NACHRA3
  • LNCR2
  • PAOD2
  • NACHRA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
trait
0.86
protein domain
0.85
biological term
0.83
microRNA
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.24   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.24   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking behavior
4
4
4
2.8
99.6
cigarettes per day measurement
5
6
7
99.6
4
2
0
1.3
99.1
6
3
2
1.3
98
smoking status measurement
2
2
1
1.3
97.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking behavior
4
2.8
99.6
cigarettes per day measurement
7
99.6
0
1.3
99.1
2
1.3
98
smoking status measurement
1
1.3
97.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cholinergic receptor nicotinic alpha 3 subunit
716571
Mouse
MGI:87887
110834
Rat
RGD:2345
25101
Dog
cholinergic receptor nicotinic alpha 3 subunit
VGNC:39238
482111
Horse
cholinergic receptor nicotinic alpha 3 subunit
VGNC:16524
100060452
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cholinergic receptor nicotinic alpha 3 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic alpha 3 subunit
Horse
cholinergic receptor nicotinic alpha 3 subunit
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32297-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (49)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Highly sodium permeable acetylcholine nicotinic receptors
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly sodium permeable acetylcholine nicotinic receptors
Neuronal System
Protein-Protein Interactions (91)
1 – 10 of 91
GLT8D2
Tbio
Family: Enzyme
Novelty: 0.79488367
p_int: 0.999579184
p_ni: 0.000420812
p_wrong: 4e-9
Data Source: BioPlex
TMEM231
Tbio
Novelty: 0.17100188
p_int: 0.997455186
p_ni: 0.002544808
p_wrong: 7e-9
Data Source: BioPlex
EDA
Tbio
Novelty: 0.00352464
p_int: 0.996599603
p_ni: 0.003400366
p_wrong: 3.1e-8
Data Source: BioPlex
GLRB
Tclin
Family: IC
Novelty: 0.01721113
p_int: 0.992420528
p_ni: 0.007230647
p_wrong: 0.000348825
Score: 0.202
Data Source: BioPlex,STRINGDB
TMEM219
Tdark
Novelty: 0.33292987
p_int: 0.992382475
p_ni: 0.007553667
p_wrong: 0.000063857
Data Source: BioPlex
LEMD2
Tbio
Novelty: 0.12460123
p_int: 0.990450314
p_ni: 0.009549686
Data Source: BioPlex
TMEM143
Tdark
Novelty: 1.58941369
p_int: 0.989418744
p_ni: 0.010544919
p_wrong: 0.000036336
Score: 0.169
Data Source: BioPlex,STRINGDB
CNNM1
Tdark
Novelty: 0.11053515
p_int: 0.984189905
p_ni: 0.015809768
p_wrong: 3.26e-7
Score: 0.285
Data Source: BioPlex,STRINGDB
TPST2
Tbio
Family: Enzyme
Novelty: 0.02551048
p_int: 0.982612574
p_ni: 0.016853458
p_wrong: 0.000533968
Score: 0.222
Data Source: BioPlex,STRINGDB
ENTPD7
Tbio
Family: Enzyme
Novelty: 0.1810079
p_int: 0.978078545
p_ni: 0.020100137
p_wrong: 0.001821318
Data Source: BioPlex
Publication Statistics
PubMed Score  146.24

PubMed score by year
PubTator Score  98.54

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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