Tclin CHRNA3 Neuronal acetylcholine receptor subunit alpha-3

Protein Summary

Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• P32297
• Q15823
• Q4KMN8
• Q86U77
• Q96RH3
• Q99553
• Q9BQ93
• Q9BRR4

Gene Name

• CHRNA3

Ensembl ID

• ENST00000326828
• ENSP00000315602
• ENSG00000080644
• ENST00000348639
• ENSP00000267951
• ENST00000559658
• ENSP00000452896

Symbol

• NACHRA3
• LNCR2
• PAOD2
• NACHRA3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
trait	0.86
protein domain	0.85
biological term	0.83
microRNA	0.83

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Acetylcholine Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-3

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Gaba Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-3

Protein / Receptor / Ligand-gated Ion Channel / Acetylcholine Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-3

Protein / Receptor / Ligand-gated Ion Channel / Gaba Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-3

DTO Classes

Protein / Ion Channel / Neurotransmitter Receptor, Cys Loop, Ligand-gated Ion Channel (Lic) Family / Acetylcholine Receptor Subfamily / Alpha-3/chrna3 Sub-subfamily / Neuronal Acetylcholine Receptor Subunit Alpha-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.02   (req: < 5)

Gene RIFs: 151   (req: <= 3)

Antibodies: 276   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.02   (req: >= 5)

Gene RIFs: 151   (req: > 3)

Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4