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Tchem
GPR183
G-protein coupled receptor 183

Protein Summary
Description
G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 tha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376414
  • ENSP00000365596
  • ENSG00000169508

Symbol
  • EBI2
  • EBI2
  • hEBI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
PubMedID
0.78
tissue sample
0.67
tissue
0.64
biological process
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.09   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.09   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (87)
25-hydroxycholesterol
Rendered image for 25-hydroxycholesterol
SID174315875
Rendered image for SID174315875
SID174315901
Rendered image for SID174315901
SID174315860
Rendered image for SID174315860
Protein-Protein Interactions (296)
Q9HDB5
Tbio
Novelty:  0.00999084
p_int:  0.999999686
p_ni:  3.11e-7
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999999681
p_ni:  3.18e-7
p_wrong:  1e-9
Data Source:  BioPlex
GPC1
Tbio
Novelty:  0.00293087
p_int:  0.999999528
p_ni:  4.72e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
TSHZ3
Tbio
Family:  TF
Novelty:  0.02963612
p_int:  0.999997153
p_ni:  0.000002817
p_wrong:  3.1e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
TMEFF1
Tbio
Novelty:  0.11856207
p_int:  0.999992146
p_ni:  1.22e-7
p_wrong:  0.000007732
Data Source:  BioPlex
TMED8
Tdark
Novelty:  1.41977071
p_int:  0.999986342
p_ni:  0.000003781
p_wrong:  0.000009877
Score:  0.181
Data Source:  BioPlex,STRINGDB
STAG2
Tbio
Novelty:  0.00430441
p_int:  0.999970769
p_ni:  0.000029231
Data Source:  BioPlex
EIF2B1
Tbio
Novelty:  0.02520554
p_int:  0.999909886
p_ni:  0.00009009
p_wrong:  2.4e-8
Score:  0.518
Data Source:  BioPlex,STRINGDB
TGFBR3
Tbio
Novelty:  0.0077307
p_int:  0.999883983
p_ni:  0.000116017
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.999858056
p_ni:  0.000141944
Score:  0.264
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
94.4
eosinophil percentage of leukocytes
2
2
2
89.6
4
4
0
1.1
88.3
2
2
0
1.1
73.4
childhood onset asthma
2
1
0
1.1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
94.4
eosinophil percentage of leukocytes
2
89.6
0
1.1
88.3
0
1.1
73.4
childhood onset asthma
0
1.1
72.3
Find similar targets by:
IDG Resources
Genetic Construct
GPR183-Tango
image for GPR183-Tango
Details:
  • Vector:  addgene66342
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR183-Tango
Order Genetic Construct from:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 183
VGNC:8877
467308
Macaque
G protein-coupled receptor 183
698844
Mouse
MGI:2442034
321019
Rat
RGD:1598095
679975
Dog
G protein-coupled receptor 183
VGNC:41423
102154241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 183
Macaque
G protein-coupled receptor 183
Mouse
Rat
Dog
G protein-coupled receptor 183
Publication Statistics
PubMed Score 69.09
PubMed score by year
PubTator Score 33.58
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title