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Tbio
CCR7
C-C chemokine receptor type 7

Protein Summary
Description
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246657
  • ENSP00000246657
  • ENSG00000126353

Symbol
  • CMKBR7
  • EBI1
  • EVI1
  • BLR2
  • EBI1
  • CCR-7
  • CD197
  • CDw197
  • CMKBR7
  • CC-CKR-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.84
PubMedID
0.82
phenotype
0.8
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1132.79   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 969   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1132.79   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 969   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
52.9
monocyte count
1
1
1
45.8
lymphocyte percentage of leukocytes
1
1
1
40.6
neutrophil percentage of leukocytes
1
1
1
31.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
52.9
monocyte count
1
45.8
lymphocyte percentage of leukocytes
1
40.6
neutrophil percentage of leukocytes
1
31.3
Pathways (17)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (61)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (508)
1 – 10 of 508
CCL21
Tbio
Novelty: 0.00130736
Score: 0.997
Data Source: Reactome,STRINGDB
CCL19
Tbio
Novelty: 0.00169711
Score: 0.996
Data Source: Reactome,STRINGDB
S1PR4
Tclin
Family: GPCR
Novelty: 0.01523676
Score: 0.972
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.972
Data Source: STRINGDB
CXCL13
Tbio
Novelty: 0.00118688
Score: 0.972
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.971
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.969
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.968
Data Source: STRINGDB
S1PR1
Tclin
Family: GPCR
Novelty: 0.00162513
Score: 0.967
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  1132.79

PubMed score by year
PubTator Score  604.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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