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Tchem
CCR1
C-C chemokine receptor type 1

Protein Summary
Description
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and paras ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296140
  • ENSP00000296140
  • ENSG00000163823

Symbol
  • CMKBR1
  • CMKR1
  • SCYAR1
  • CKR1
  • CD191
  • CKR-1
  • HM145
  • CMKBR1
  • MIP1aR
  • SCYAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
1
biological process
0.93
molecular function
0.91
biological term
0.72
phenotype
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.84   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 480   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.84   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 400
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (391)
OCC1
Tbio
Novelty:  0.05175429
p_int:  0.989409839
p_ni:  0.00818331
p_wrong:  0.002406852
Score:  0.189
Data Source:  BioPlex,STRINGDB
GNG10
Tdark
Novelty:  0.37659459
p_int:  0.982240675
p_ni:  0.015610855
p_wrong:  0.00214847
Score:  0.929
Data Source:  BioPlex,STRINGDB
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.968151208
p_ni:  0.031834441
p_wrong:  0.000014351
Score:  0.219
Data Source:  BioPlex,STRINGDB
GAP43
Tbio
Novelty:  0.00091023
p_int:  0.936982189
p_ni:  0.063017811
Score:  0.196
Data Source:  BioPlex,STRINGDB
EPHA2
Tclin
Family:  Kinase
Novelty:  0.00191002
p_int:  0.930026402
p_ni:  0.069694096
p_wrong:  0.000279502
Score:  0.212
Data Source:  BioPlex,STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.925014433
p_ni:  0.074985567
Data Source:  BioPlex
LENG1
Tdark
Novelty:  1.81219077
p_int:  0.914374059
p_ni:  0.001874277
p_wrong:  0.083751665
Score:  0.232
Data Source:  BioPlex,STRINGDB
STXBP2
Tbio
Novelty:  0.01896992
p_int:  0.906781279
p_ni:  0.02565669
p_wrong:  0.067562031
Score:  0.218
Data Source:  BioPlex,STRINGDB
YES1
Tclin
Family:  Kinase
Novelty:  0.00534936
p_int:  0.835171088
p_ni:  0.164828791
p_wrong:  1.2e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
CDCA3
Tbio
Novelty:  0.05136899
p_int:  0.82307485
p_ni:  0.17692515
Score:  0.194
Data Source:  BioPlex,STRINGDB
Pathways (22)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (76)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
3
3
93.4
CCL2 measurement
3
4
4
91.3
4
4
0
1.3
89
Oral ulcer
1
2
0
1.1
88.1
macrophage inflammatory protein 1b measurement
1
1
1
87.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
93.4
CCL2 measurement
4
91.3
0
1.3
89
Oral ulcer
0
1.1
88.1
macrophage inflammatory protein 1b measurement
1
87.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine receptor 1
574188
Mouse
MGI:104618
12768
Rat
RGD:708446
57301
Cow
chemokine (C-C motif) receptor 1
407771
Pig
C-C motif chemokine receptor 1
414374
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine receptor 1
Mouse
Rat
Cow
chemokine (C-C motif) receptor 1
Pig
C-C motif chemokine receptor 1
Publication Statistics
PubMed Score 426.84
PubMed score by year
PubTator Score 298.41
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title