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Tclin
MC4R
Melanocortin receptor 4

Protein Summary
Description
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299766
  • ENSP00000299766
  • ENSG00000166603
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.79
molecular function
0.73
protein domain
0.73
disease
0.71
biological term
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 998.33   (req: < 5)
Gene RIFs: 286   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 998.33   (req: >= 5)
Gene RIFs: 286   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1090
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bremelanotide
chemical structure image
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (235)
1 – 10 of 235
POMC
Tbio
Novelty: 0.00002654
Score: 0.996
Data Source: Reactome,STRINGDB
AGRP
Tbio
Novelty: 0.00207876
Score: 0.995
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.00017805
Score: 0.979
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00011983
Score: 0.978
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00005614
Score: 0.953
Data Source: STRINGDB
GIPR
Tchem
Family: GPCR
Novelty: 0.01383046
Score: 0.95
Data Source: STRINGDB
GLP1R
Tclin
Family: GPCR
Novelty: 0.00098883
Score: 0.947
Data Source: STRINGDB
CRHR1
Tclin
Family: GPCR
Novelty: 0.00121307
Score: 0.941
Data Source: STRINGDB
IAPP
Tbio
Novelty: 0.00059438
Score: 0.94
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0043523
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  998.33

PubMed score by year
PubTator Score  712.16

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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