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Tbio
OTX1
Homeobox protein OTX1

Protein Summary
Description
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282549
  • ENSP00000282549
  • ENSG00000115507
  • ENST00000366671
  • ENSP00000355631
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.81
molecular function
0.79
transcription factor binding site profile
0.76
gene perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.73   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.73   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
3
1
0
1.1
87.2
risk-taking behaviour
1
1
1
41.5
diet measurement
1
1
1
9.4
social interaction measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
87.2
risk-taking behaviour
1
41.5
diet measurement
1
9.4
social interaction measurement
1
0.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
orthodenticle homeobox 1
VGNC:50339
744025
Macaque
orthodenticle homeobox 1
694175
Mouse
MGI:97450
18423
Rat
RGD:3237
25646
Dog
orthodenticle homeobox 1
VGNC:44193
610347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
orthodenticle homeobox 1
Macaque
orthodenticle homeobox 1
Mouse
Rat
Dog
orthodenticle homeobox 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P32242-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
Signaling pathways regulating pluripotency of stem cells
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (52)
1 – 10 of 52
WDR70
Tdark
Novelty: 0.37521871
Score: 0.692
Data Source: STRINGDB
LMX1A
Tbio
Family: TF
Novelty: 0.0104588
Score: 0.648
Data Source: STRINGDB
PAX2
Tbio
Family: TF
Novelty: 0.00160808
Score: 0.635
Data Source: STRINGDB
LHX2
Tbio
Family: TF
Novelty: 0.00915095
Score: 0.632
Data Source: STRINGDB
FOXG1
Tbio
Family: TF
Novelty: 0.00154897
Score: 0.622
Data Source: STRINGDB
KRT81
Tbio
Novelty: 0.05514238
Score: 0.612
Data Source: STRINGDB
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.609
Data Source: STRINGDB
TGM7
Tdark
Family: Enzyme
Novelty: 0.24105204
Score: 0.602
Data Source: STRINGDB
FEZF2
Tbio
Family: TF
Novelty: 0.01641588
Score: 0.59
Data Source: STRINGDB
TLE4
Tbio
Novelty: 0.02094922
Score: 0.584
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.73

PubMed score by year
PubTator Score  25.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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