VIPR1
Vasoactive intestinal polypeptide receptor 1
Protein Summary
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38. This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000325123
- ENSP00000327246
- ENSG00000114812
- ENST00000433647
- ENSP00000394950
- ENST00000438259
- ENSP00000415371
- ENST00000543411
- ENSP00000445701
- II
- HVR1
- RDC1
- V1RG
- VIPR
- VIRG
- VAPC1
- VPAC1
- VPAC1R
- VIP-R-1
- VPCAP1R
- PACAP-R2
- PACAP-R-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (protein) | 0.85 | ||
protein domain | 0.85 | ||
PubMedID | 0.65 | ||
gene perturbation | 0.63 | ||
small molecule perturbation | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 655.05 (req: < 5)
Gene RIFs: 66 (req: <= 3)
Antibodies: 423 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 655.05 (req: >= 5)
Gene RIFs: 66 (req: > 3)
Antibodies: 423 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0