You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CCKBR
Gastrin/cholecystokinin type B receptor

Protein Summary
Description
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334619
  • ENSP00000335544
  • ENSG00000110148
  • ENST00000525462
  • ENSP00000435534

Symbol
  • CCKRB
  • GASR
  • CCK-B
  • CCK2R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.97
molecular function
0.95
gene perturbation
0.78
phenotype
0.76
disease
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 581.05   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 581.05   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 573
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
proglumide
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
29.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
29.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholecystokinin B receptor
VGNC:3160
466414
Macaque
cholecystokinin B receptor
712939
Mouse
MGI:99479
12426
Rat
RGD:2290
25706
Dog
cholecystokinin B receptor [Source:HGNC Symbol;Acc:HGNC:1571]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholecystokinin B receptor
Macaque
cholecystokinin B receptor
Mouse
Rat
Dog
cholecystokinin B receptor [Source:HGNC Symbol;Acc:HGNC:1571]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P32239-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Gastrin-CREB signalling pathway via PKC and MAPK
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gastrin-CREB signalling pathway via PKC and MAPK
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (205)
1 – 10 of 205
GMCL1
Tbio
Novelty: 0.1543762
p_int: 0.998482142
p_ni: 0.001445837
p_wrong: 0.000072021
Data Source: BioPlex
KIRREL1
Tbio
Novelty: 0.03216031
p_int: 0.998323948
p_ni: 0.001676052
Score: 0.158
Data Source: BioPlex,STRINGDB
PXK
Tbio
Family: Kinase
Novelty: 0.02316511
p_int: 0.996341771
p_ni: 0.003658226
p_wrong: 3e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
PRKAB1
Tchem
Family: Kinase
Novelty: 0.01610606
p_int: 0.962409571
p_ni: 0.037590368
p_wrong: 6e-8
Score: 0.696
Data Source: BioPlex,STRINGDB
PRKAA1
Tclin
Family: Kinase
Novelty: 0.01205826
p_int: 0.93975903
p_ni: 0.06024097
Score: 0.812
Data Source: BioPlex,STRINGDB
PRKAG1
Tbio
Family: Kinase
Novelty: 0.07735301
p_int: 0.855361357
p_ni: 0.144638514
p_wrong: 1.29e-7
Score: 0.82
Data Source: BioPlex,STRINGDB
THADA
Tbio
Novelty: 0.06983966
p_int: 0.849484256
p_ni: 0.150515744
Score: 0.163
Data Source: BioPlex,STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.998
Data Source: Reactome,STRINGDB
GAST
Tbio
Novelty: 0.00011795
Score: 0.997
Data Source: Reactome,STRINGDB
GRP
Tbio
Novelty: 0.00034247
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  581.05

PubMed score by year
PubTator Score  452.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: