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Tclin
CCKAR
Cholecystokinin receptor type A

Protein Summary
Description
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295589
  • ENSP00000295589
  • ENSG00000163394

Symbol
  • CCKRA
  • CCK-A
  • CCK1R
  • CCKRA
  • CCK1-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
ligand (chemical)
0.91
disease perturbation
0.83
phenotype
0.73
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 583.52   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 583.52   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 210
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Physical Interaction (IPI)
GO_Central
Protein-Protein Interactions (188)
1 – 10 of 188
CCK
Tbio
Novelty: 0.00012268
Score: 0.997
Data Source: Reactome,STRINGDB
GAST
Tbio
Novelty: 0.00011795
Score: 0.989
Data Source: STRINGDB
GRP
Tbio
Novelty: 0.00034247
Score: 0.954
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.951
Data Source: STRINGDB
P2RY6
Tchem
Family: GPCR
Novelty: 0.00676114
Score: 0.95
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.948
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.945
Data Source: STRINGDB
CCKBR
Tclin
Family: GPCR
Novelty: 0.00158159
Score: 0.939
Data Source: STRINGDB
OXT
Tbio
Novelty: 0.00005116
Score: 0.938
Data Source: STRINGDB
HCRT
Tbio
Novelty: 0.00034048
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  583.52

PubMed score by year
PubTator Score  250.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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