Tclin CCKAR Cholecystokinin receptor type A

Protein Summary

Description

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P32238
• B2R9Z5
• CCK-A receptor

Gene Name

• CCKAR

Ensembl ID

• ENST00000295589
• ENSP00000295589
• ENSG00000163394

Symbol

• CCKRA
• CCK-A
• CCK1R
• CCKRA
• CCK1-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.95
ligand (chemical)	0.91
disease perturbation	0.83
phenotype	0.73
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Cholecystokinin Receptor Type A

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Cholecystokinin Receptor / Cholecystokinin Receptor Type A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.53   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 412   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.53   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 262

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2