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Tbio
ARRB2
Beta-arrestin-2

Protein Summary
Description
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269260
  • ENSP00000269260
  • ENSG00000141480
  • ENST00000346341
  • ENSP00000341895
  • ENST00000381488
  • ENSP00000370898
  • ENST00000412477
  • ENSP00000403701

Symbol
  • ARB2
  • ARR2
  • ARB2
  • ARR2
  • BARR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
protein domain
0.92
molecular function
0.9
cellular component
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.15   (req: < 5)
Gene RIFs: 198   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.15   (req: >= 5)
Gene RIFs: 198   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
83.1
C-X-C motif chemokine 16 measurement
1
1
1
29.8
leukocyte count
1
1
1
16.4
blood protein measurement
1
1
1
16
lymphocyte percentage of leukocytes
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
83.1
C-X-C motif chemokine 16 measurement
1
29.8
leukocyte count
1
16.4
blood protein measurement
1
16
lymphocyte percentage of leukocytes
1
4.9
Pathways (81)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Activation of SMO
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Activation of SMO
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Gene Ontology Terms (82)
Items per page:
10
1 – 10 of 20
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (783)
1 – 10 of 783
ARRB1
Tbio
Novelty: 0.00262758
p_int: 1
Score: 0.968
Data Source: BioPlex,STRINGDB
ARR3
Tbio
Novelty: 0.00575939
p_int: 0.999999919
p_wrong: 8.1e-8
Score: 0.375
Data Source: BioPlex,STRINGDB
KANK1
Tbio
Novelty: 0.02077359
p_int: 0.999999642
p_ni: 3.58e-7
Score: 0.213
Data Source: BioPlex,STRINGDB
BRPF1
Tchem
Family: Epigenetic
Novelty: 0.02524021
p_int: 0.999998135
p_ni: 0.000001863
p_wrong: 2e-9
Score: 0.65
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999990192
p_ni: 0.000009808
Data Source: BioPlex
DIEXF
Tbio
Novelty: 0.05892659
p_int: 0.999961745
p_ni: 0.000036846
p_wrong: 0.000001408
Data Source: BioPlex
NAA15
Tbio
Family: Enzyme
Novelty: 0.00513055
p_int: 0.999933599
p_ni: 0.000066401
Data Source: BioPlex
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
p_int: 0.99990018
p_ni: 0.00009982
Score: 0.659
Data Source: BioPlex,STRINGDB
RFX1
Tbio
Family: TF
Novelty: 0.00225236
p_int: 0.999398822
p_ni: 0.000601178
Data Source: BioPlex
WDR70
Tdark
Novelty: 0.37521871
p_int: 0.998989784
p_ni: 0.000328176
p_wrong: 0.00068204
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  678.15

PubMed score by year
PubTator Score  306.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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