Protein Classes
Protein Summary
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, ...more
- ENST00000269260
- ENSP00000269260
- ENSG00000141480
- ENST00000346341
- ENSP00000341895
- ENST00000381488
- ENSP00000370898
- ENST00000412477
- ENSP00000403701
- ARB2
- ARR2
- ARB2
- ARR2
- BARR2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
protein domain | 0.92 | ||
molecular function | 0.9 | ||
cellular component | 0.87 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 517.05 (req: < 5)
Gene RIFs: 198 (req: <= 3)
Antibodies: 338 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 517.05 (req: >= 5)
Gene RIFs: 198 (req: > 3)
Antibodies: 338 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 69
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (81)
Reactome (42)
KEGG (10)
PathwayCommons (20)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 42
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Activation of SMO | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Activation of SMO | ||||
Beta-catenin independent WNT signaling | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Gene Ontology Terms (82)
Functions (20)
Components (13)
Processes (49)
Items per page:
10
1 – 10 of 20
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (783)
1 – 10 of 783
ARRB1
Novelty: 0.00194842
p_int: 1
Score: 0.968
Data Source: BioPlex,STRINGDB
ARR3
Novelty: 0.00699055
p_int: 0.999999919
p_wrong: 8.1e-8
Score: 0.375
Data Source: BioPlex,STRINGDB
KANK1
Novelty: 0.02567682
p_int: 0.999999642
p_ni: 3.58e-7
Score: 0.213
Data Source: BioPlex,STRINGDB
BRPF1
Family: Epigenetic
Novelty: 0.00091567
p_int: 0.999998135
p_ni: 0.000001863
p_wrong: 2e-9
Score: 0.65
Data Source: BioPlex,STRINGDB
SLC9A3R2
Family: Transporter
Novelty: 0.01296563
p_int: 0.999990192
p_ni: 0.000009808
Data Source: BioPlex
DIEXF
Novelty: 0.03636364
p_int: 0.999961745
p_ni: 0.000036846
p_wrong: 0.000001408
Data Source: BioPlex
NAA15
Family: Enzyme
Novelty: 0.00751608
p_int: 0.999933599
p_ni: 0.000066401
Data Source: BioPlex
RTF1
Family: Enzyme
Novelty: 0.03564965
p_int: 0.99990018
p_ni: 0.00009982
Score: 0.659
Data Source: BioPlex,STRINGDB
RFX1
Family: TF
Novelty: 0.0029798
p_int: 0.999398822
p_ni: 0.000601178
Data Source: BioPlex
WDR70
Novelty: 1.2244898
p_int: 0.998989784
p_ni: 0.000328176
p_wrong: 0.00068204
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 517.05
PubMed score by year
PubTator Score 306.06
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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