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Tbio
PRDX2
Peroxiredoxin-2

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301522
  • ENSP00000301522
  • ENSG00000167815

Symbol
  • NKEFB
  • TDPX1
  • PRP
  • TSA
  • PRX2
  • PTX1
  • TPX1
  • NKEFB
  • PRXII
  • TDPX1
  • NKEF-B
  • HEL-S-2a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
protein complex
0.99
small molecule perturbation
0.91
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 415.54   (req: < 5)
View Publications
Gene RIFs: 117   (req: <= 3)
View Gene RIFs
Antibodies: 490   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 415.54   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 490   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (65)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
487 targets
R-HSA-8953897
Reactome
Cellular responses to stress
392 targets
R-HSA-2262752
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
22 targets
R-HSA-8862803
Reactome
Detoxification of Reactive Oxygen Species
37 targets
R-HSA-3299685
Reactome
Disease
1105 targets
R-HSA-1643685
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
487 targets
R-HSA-8953897
Cellular responses to stress
392 targets
R-HSA-2262752
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
22 targets
R-HSA-8862803
Detoxification of Reactive Oxygen Species
37 targets
R-HSA-3299685
Disease
1105 targets
R-HSA-1643685
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
antioxidant activity
Inferred from Direct Assay (IDA)
UniProtKB
thioredoxin peroxidase activity
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (177)
1 – 10 of 177
TRAPPC12
Tbio
Novelty: 0.05825243
p_int: 0.999541872
p_ni: 0.000458128
Data Source: BioPlex
FAM171A2
Tdark
Novelty: 7
p_int: 0.998650376
p_ni: 0.001349616
p_wrong: 8e-9
Data Source: BioPlex
UBB
Tbio
Novelty: 0.00895161
p_int: 0.997871572
p_ni: 0.002105889
p_wrong: 0.00002254
Score: 0.291
Data Source: BioPlex,STRINGDB
TXNDC9
Tbio
Novelty: 0.00444155
p_int: 0.993002572
p_ni: 0.006997428
Score: 0.351
Data Source: BioPlex,STRINGDB
ANKRD40
Tdark
p_int: 0.989316198
p_ni: 0.010683801
Data Source: BioPlex
CCT2
Tbio
Novelty: 0.03021537
p_int: 0.985184173
p_ni: 0.014815827
Score: 0.297
Data Source: BioPlex,STRINGDB
TCP1
Tbio
Novelty: 0.00509212
p_int: 0.981502773
p_ni: 0.018497227
Score: 0.365
Data Source: BioPlex,STRINGDB
CCT6A
Tbio
Novelty: 0.03886926
p_int: 0.971167258
p_ni: 0.028832742
Score: 0.254
Data Source: BioPlex,STRINGDB
CCT7
Tbio
Novelty: 0.03353089
p_int: 0.968595061
p_ni: 0.031404939
Score: 0.201
Data Source: BioPlex,STRINGDB
CCT6B
Tdark
Novelty: 0.35608309
p_int: 0.960839909
p_ni: 0.039160089
p_wrong: 2e-9
Score: 0.186
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  415.54

PubMed score by year
PubTator Score  249.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGC
1-70
EVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQ
70-140
ITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN
140-198
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN