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Tbio
PRDX2
Peroxiredoxin-2

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301522
  • ENSP00000301522
  • ENSG00000167815

Symbol
  • NKEFB
  • TDPX1
  • PRP
  • TSA
  • PRX2
  • PTX1
  • TPX1
  • NKEFB
  • PRXII
  • TDPX1
  • NKEF-B
  • HEL-S-2a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
protein complex
0.99
small molecule perturbation
0.91
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.67   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 490   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.67   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 490   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.999541872
p_ni:  0.000458128
Data Source:  BioPlex
FAM171A2
Tdark
Novelty:  1.18763693
p_int:  0.998650376
p_ni:  0.001349616
p_wrong:  8e-9
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.997871572
p_ni:  0.002105889
p_wrong:  0.00002254
Score:  0.291
Data Source:  BioPlex,STRINGDB
TXNDC9
Tbio
Novelty:  0.00309772
p_int:  0.993002572
p_ni:  0.006997428
Score:  0.351
Data Source:  BioPlex,STRINGDB
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.989316198
p_ni:  0.010683801
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.985184173
p_ni:  0.014815827
Score:  0.297
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.981502773
p_ni:  0.018497227
Score:  0.365
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.971167258
p_ni:  0.028832742
Score:  0.254
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.968595061
p_ni:  0.031404939
Score:  0.201
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.960839909
p_ni:  0.039160089
p_wrong:  2e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Detoxification of Reactive Oxygen Species
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
6
6
98.2
reticulocyte measurement
3
4
5
97.2
mean corpuscular hemoglobin concentration
3
3
3
97
reticulocyte count
7
3
7
94.2
erythrocyte count
3
3
3
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
6
98.2
reticulocyte measurement
5
97.2
mean corpuscular hemoglobin concentration
3
97
reticulocyte count
7
94.2
erythrocyte count
3
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxiredoxin 2
VGNC:2281
468740
Macaque
peroxiredoxin 2
716665
Mouse
MGI:109486
21672
Rat
RGD:3838
29338
Dog
peroxiredoxin 2
VGNC:44951
100856470
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxiredoxin 2
Macaque
peroxiredoxin 2
Mouse
Rat
Dog
peroxiredoxin 2
Publication Statistics
PubMed Score 556.67
PubMed score by year
PubTator Score 249.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title