Tbio CEACAM8 Carcinoembryonic antigen-related cell adhesion molecule 8

Protein Summary

Description

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).

Uniprot Accession IDs

• P31997
• O60399
• Q16574

Gene Name

• CEACAM8

Ensembl ID

• ENST00000244336
• ENSP00000244336
• ENSG00000124469

Symbol

• CGM6
• CD67
• CGM6
• CD66b
• NCA-95

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
disease	0.58
protein domain	0.58
microRNA	0.57
cellular component	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.72   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 468   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.72   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0