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Tdark
FCGR2C
Low affinity immunoglobulin gamma Fc region receptor II-c

Protein Classes
Protein Summary
Description
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Symbol
  • CD32
  • FCG2
  • IGFR2
  • CD32
  • FCG2
  • CD32C
  • CDW32
  • IGFR2
  • FCRIIC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.81
kinase
0.62
hub protein
0.58
tissue sample
0.56
small molecule perturbation
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Staphylococcus aureus infection
KEGG
Phagosome
KEGG
Tuberculosis
KEGG
Leishmaniasis
KEGG
Osteoclast differentiation
Name
Explore in Pharos
Explore in Source
Staphylococcus aureus infection
Phagosome
Tuberculosis
Leishmaniasis
Osteoclast differentiation
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (1)
1 – 1 of 1
FCGR2A
Tbio
Novelty: 0.00116226
p_int: 0.997858099
p_ni: 1e-9
p_wrong: 0.0021419
Data Source: BioPlex
Publication Statistics
PubTator Score  36.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer