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Tbio
FCGR2B
Low affinity immunoglobulin gamma Fc region receptor II-b

Protein Classes
Protein Summary
Description
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236937
  • ENSP00000236937
  • ENSG00000072694
  • ENST00000358671
  • ENSP00000351497
  • ENST00000367961
  • ENSP00000356938

Symbol
  • CD32
  • FCG2
  • IGFR2
  • CD32
  • FCG2
  • CD32B
  • FCGR2
  • IGFR2
  • FCGR2C
  • FcRII-c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
transcription factor perturbation
0.91
drug
0.83
phenotype
0.8
disease
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 887.96   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 745   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 887.96   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 745   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
20
20
99.9
blood protein measurement
2
18
18
99.8
aspartate aminotransferase measurement
2
2
1
10.9
93.9
serum gamma-glutamyl transferase measurement
2
3
3
92.6
basophil percentage of leukocytes
1
3
3
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
20
99.9
blood protein measurement
18
99.8
aspartate aminotransferase measurement
1
10.9
93.9
serum gamma-glutamyl transferase measurement
3
92.6
basophil percentage of leukocytes
3
91.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor [Source:RefSeq peptide;Acc:NP_001244231]
Mouse
MGI:95499
14130
Dog
low affinity immunoglobulin gamma Fc region receptor II
100856270
Cow
Fc fragment of IgG receptor IIb
282229
Pig
Fc fragment of IgG, low affinity IIb, receptor (CD32)
613131
Species
Name
OMA
EggNOG
Inparanoid
Macaque
low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor [Source:RefSeq peptide;Acc:NP_001244231]
Mouse
Dog
low affinity immunoglobulin gamma Fc region receptor II
Cow
Fc fragment of IgG receptor IIb
Pig
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31994-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein-Protein Interactions (265)
1 – 10 of 265
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.998176437
p_ni:  0.001004049
p_wrong:  0.000819514
Score:  0.534
Data Source:  BioPlex,STRINGDB
FCGR2A
Tbio
Novelty:  0.00078918
p_int:  0.992167965
p_ni:  2e-9
p_wrong:  0.007832033
Score:  0.656
Data Source:  BioPlex,STRINGDB
MARS2
Tbio
Family:  Enzyme
Novelty:  0.02533315
p_int:  0.990995636
p_ni:  0.007851469
p_wrong:  0.001152895
Score:  0.534
Data Source:  BioPlex,STRINGDB
INPP5D
Tbio
Family:  Enzyme
Novelty:  0.00630254
Score:  0.974
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.972
Data Source:  STRINGDB
DOK1
Tbio
Novelty:  0.01976327
Score:  0.94
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.939
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.939
Data Source:  STRINGDB
MS4A2
Tbio
Novelty:  0.07049421
Score:  0.938
Data Source:  STRINGDB
IGLC1
Tdark
Novelty:  0.00459259
Score:  0.936
Data Source:  STRINGDB
Publication Statistics
PubMed Score  887.96

PubMed score by year
PubTator Score  303.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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