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Tbio
S100A11
Protein S100-A11

Protein Summary
Description
Facilitates the differentiation and the cornification of keratinocytes. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271638
  • ENSP00000271638
  • ENSG00000163191

Symbol
  • MLN70
  • S100C
  • MLN70
  • S100C
  • HEL-S-43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
interacting protein
0.91
PubMedID
0.88
protein domain
0.85
tissue
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.81   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.81   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
1
1
66.7
2
1
2
26.7
age at onset
1
1
1
22.8
1
1
0
1.2
9.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
66.7
2
26.7
age at onset
1
22.8
0
1.2
9.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A11
VGNC:1523
457994
Macaque
S100 calcium binding protein A11
717324
Mouse
MGI:1338798
20195
Rat
RGD:1303295
445415
Dog
S100 calcium binding protein A11
VGNC:54355
475852
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A11
Macaque
S100 calcium binding protein A11
Mouse
Rat
Dog
S100 calcium binding protein A11
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31949-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (62)
1 – 10 of 62
VEZT
Tbio
Novelty: 0.06274137
p_int: 0.930546927
p_ni: 0.069453073
Data Source: BioPlex
NCL
Tbio
Novelty: 0.00100905
Score: 0.933
Data Source: STRINGDB
ANXA1
Tbio
Novelty: 0.00103537
Score: 0.924
Data Source: STRINGDB
ANXA2
Tbio
Novelty: 0.00103362
Score: 0.882
Data Source: STRINGDB
ANXA6
Tbio
Novelty: 0.00286706
Score: 0.707
Data Source: STRINGDB
LELP1
Tbio
Novelty: 0.70511274
Score: 0.683
Data Source: STRINGDB
AHNAK
Tbio
Novelty: 0.01201996
Score: 0.681
Data Source: STRINGDB
S100A7
Tbio
Novelty: 0.00434262
Score: 0.678
Data Source: STRINGDB
SPRR4
Tdark
Novelty: 0.25132059
Score: 0.663
Data Source: STRINGDB
DIAPH1
Tbio
Novelty: 0.0150259
Score: 0.658
Data Source: STRINGDB
Publication Statistics
PubMed Score  154.81

PubMed score by year
PubTator Score  86.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer