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Tbio
SFN
14-3-3 protein sigma

Protein Summary
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. p53-regulated inhibitor of G2/M progression. This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339276
  • ENSP00000340989
  • ENSG00000175793

Symbol
  • HME1
  • YWHAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
biological process
0.96
interacting protein
0.89
gene perturbation
0.85
disease perturbation
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.51   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 694   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.51   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 694   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (202)
TRIM62
Tbio
Family:  Enzyme
Novelty:  0.12565021
p_int:  0.999718457
p_ni:  0.000252478
p_wrong:  0.000029065
Score:  0.276
Data Source:  BioPlex,STRINGDB
PLD6
Tbio
Family:  Enzyme
Novelty:  0.02802141
p_int:  0.994238468
p_ni:  0.005275968
p_wrong:  0.000485565
Score:  0.253
Data Source:  BioPlex,STRINGDB
FAM86C1
Tdark
Family:  Enzyme
Novelty:  1.61781609
p_int:  0.986814725
p_ni:  0.013185275
Data Source:  BioPlex
SMTNL2
Tdark
Novelty:  0.33805653
p_int:  0.985359042
p_ni:  0.014640958
Score:  0.831
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.976571354
p_ni:  0.023428646
Score:  0.976
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.968866145
p_ni:  0.031133855
Score:  0.976
Data Source:  BioPlex,STRINGDB
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.917423597
p_ni:  0.082576403
Score:  0.823
Data Source:  BioPlex,STRINGDB
YWHAB
Tbio
Novelty:  0.00614093
p_int:  0.90878488
p_ni:  0.09121512
Score:  0.968
Data Source:  BioPlex,STRINGDB
YWHAQ
Tbio
Novelty:  0.00234496
p_int:  0.848279079
p_ni:  0.151720921
Score:  0.985
Data Source:  BioPlex,STRINGDB
CBY1
Tbio
Novelty:  0.0205109
Score:  0.988
Data Source:  STRINGDB
Pathways (67)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

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Find Similar Targets
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Apoptosis
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Apoptosis
Cell Cycle
Cell Cycle Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (55)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
19
5
22
94.6
triglyceride measurement
19
4
20
94.5
low density lipoprotein cholesterol measurement
16
4
17
91.7
C-reactive protein measurement
4
1
5
91.3
serum gamma-glutamyl transferase measurement
3
3
3
84.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
22
94.6
triglyceride measurement
20
94.5
low density lipoprotein cholesterol measurement
17
91.7
C-reactive protein measurement
5
91.3
serum gamma-glutamyl transferase measurement
3
84.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stratifin
VGNC:1543
737412
Macaque
stratifin
715055
Mouse
MGI:1891831
55948
Rat
RGD:1304729
313017
Rat
RGD:1359510
298795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stratifin
Macaque
stratifin
Mouse
Rat
Rat
Publication Statistics
PubMed Score 338.51
PubMed score by year
PubTator Score 166.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title