Tchem YWHAB 14-3-3 protein beta/alpha

Protein Summary

Description

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P31946
• A8K9K2
• E1P616

Gene Name

• YWHAB

Ensembl ID

• ENST00000353703
• ENSP00000300161
• ENSG00000166913
• ENST00000372839
• ENSP00000361930

Symbol

• HS1
• GW128
• YWHAA
• KCIP-1
• HEL-S-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
interacting protein	1
kinase perturbation	1
biological process	0.98

Protein Classes

PANTHER Classes

Protein / Chaperone / 14-3-3 Protein Beta/alpha

DTO Classes

Protein / Chaperone / 14-3-3 Protein Beta/alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.48   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 652   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.48   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 652   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

PHCVPRDLSWLDLEANMCLP

YWHABTchem

pKd : 7.16

Protein-Protein Interactions (363)

Explore Interacting Targets

1 – 10 of 363

• See Interactions on String-DB

FAM86C1

Tdark

Family:  Enzyme

Novelty:  1.61781609

p_int:  0.997868503

p_ni:  0.002131497

Data Source:  BioPlex

BRAF

Tclin

Family:  Kinase

Novelty:  0.00253795

p_int:  0.995332338

p_ni:  0.004667662

Score:  0.98

Data Source:  BioPlex,Reactome,STRINGDB

SMTNL2

Tdark

Novelty:  0.33805653

p_int:  0.99467618

p_ni:  0.00532382

Score:  0.378

Data Source:  BioPlex,STRINGDB

KIAA0930

Tbio

Novelty:  0.16492958

p_int:  0.987745207

p_ni:  0.012254793

Score:  0.534

Data Source:  BioPlex,STRINGDB

GPSM3

Tbio

Novelty:  0.01632501

p_int:  0.986573761

p_ni:  0.013426239

Data Source:  BioPlex

SPATA13

Tbio

Novelty:  0.19610601

p_int:  0.980671201

p_ni:  0.019328799

Score:  0.352

Data Source:  BioPlex,STRINGDB

CGN

Tbio

Novelty:  0.01097394

p_int:  0.97077429

p_ni:  0.02922571

Score:  0.185

Data Source:  BioPlex,STRINGDB

LNP1

Tdark

Novelty:  0.00457285

p_int:  0.966455291

p_ni:  0.033544709

Data Source:  BioPlex

SAMD4A

Tbio

Novelty:  0.04440962

p_int:  0.965259315

p_ni:  0.034740685

Score:  0.51

Data Source:  BioPlex,STRINGDB

PRICKLE3

Tbio

Novelty:  0.26347141

p_int:  0.939017462

p_ni:  0.060982538

Data Source:  BioPlex

Nearest Tclin Targets (2)

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Downstream (2)

1 – 2 of 2

BCL2

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  2

1: PI3K-Akt signaling pathway

2: Hepatitis B

ITGB2

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  1

1: Hippo signaling pathway

Pathways (109)

Reactome (59)

KEGG (7)

PathwayCommons (37)

WikiPathways (6)

ARMS-mediated activation (R-HSA-170984)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ARMS-mediated activation	7 targets	R-HSA-170984
Reactome	Activation of BAD and translocation to mitochondria	15 targets	R-HSA-111447
Reactome	Activation of BH3-only proteins	31 targets	R-HSA-114452
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Apoptosis	177 targets	R-HSA-109581

Name	Explore in Pharos	Explore in Source
ARMS-mediated activation	7 targets	R-HSA-170984
Activation of BAD and translocation to mitochondria	15 targets	R-HSA-111447
Activation of BH3-only proteins	31 targets	R-HSA-114452
Adaptive Immune System	894 targets	R-HSA-1280218
Apoptosis	177 targets	R-HSA-109581

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (32)

Functions (9)

Components (10)

Processes (13)

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1 – 9 of 9

GO Term	Evidence	Assigned by
enzyme binding	Inferred from Physical Interaction (IPI)	BHF-UCL
histone deacetylase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
phosphoprotein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
phosphoserine residue binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
protein C-terminus binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (11)

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1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	2	2		90.2
basophil count	EFO_0005090	1	1	1		74.3
basophil percentage of leukocytes	EFO_0007992	1	1	1		74.2
chronotype measurement	EFO_0008328	2	1	1	1	63.7
blood protein measurement	EFO_0007937	1	1	1		47.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2		90.2
basophil count	EFO_0005090	1		74.3
basophil percentage of leukocytes	EFO_0007992	1		74.2
chronotype measurement	EFO_0008328	1	1	63.7
blood protein measurement	EFO_0007937	1		47.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative initiation
Complete proteome
Cytoplasm
Direct protein sequencing
Host-virus interaction
Isopeptide bond
Nitration
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
basophil count
basophil percentage of leukocytes
bipolar disorder
blood protein measurement
breakfast skipping measurement
chronotype measurement
lifestyle measurement
mean platelet volume
platelet count
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	VGNC:10069	458272
Macaque	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta		717788
Mouse	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	MGI:1891917	54401
Rat	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta	RGD:61998	56011
Dog	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	VGNC:48508	477237

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Macaque	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Mouse	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Rat	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Dog	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

Publication Statistics

PubMed Score 143.48

PubMed score by year

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PubTator Score 19.26

PubTator score by year

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Related Publications

Text Mined References (194)

GeneRif Annotations (49)

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PMID	Year	Title