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Tchem
YWHAB
14-3-3 protein beta/alpha

Protein Summary
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in l ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353703
  • ENSP00000300161
  • ENSG00000166913
  • ENST00000372839
  • ENSP00000361930

Symbol
  • HS1
  • GW128
  • YWHAA
  • KCIP-1
  • HEL-S-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
1
biological process
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.48   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 652   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.48   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 652   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (363)
FAM86C1
Tdark
Family:  Enzyme
Novelty:  1.61781609
p_int:  0.997868503
p_ni:  0.002131497
Data Source:  BioPlex
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.995332338
p_ni:  0.004667662
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
SMTNL2
Tdark
Novelty:  0.33805653
p_int:  0.99467618
p_ni:  0.00532382
Score:  0.378
Data Source:  BioPlex,STRINGDB
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.987745207
p_ni:  0.012254793
Score:  0.534
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.986573761
p_ni:  0.013426239
Data Source:  BioPlex
SPATA13
Tbio
Novelty:  0.19610601
p_int:  0.980671201
p_ni:  0.019328799
Score:  0.352
Data Source:  BioPlex,STRINGDB
CGN
Tbio
Novelty:  0.01097394
p_int:  0.97077429
p_ni:  0.02922571
Score:  0.185
Data Source:  BioPlex,STRINGDB
LNP1
Tdark
Novelty:  0.00457285
p_int:  0.966455291
p_ni:  0.033544709
Data Source:  BioPlex
SAMD4A
Tbio
Novelty:  0.04440962
p_int:  0.965259315
p_ni:  0.034740685
Score:  0.51
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.939017462
p_ni:  0.060982538
Data Source:  BioPlex
Pathways (109)
ARMS-mediated activation (R-HSA-170984)

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Find Similar Targets
Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARMS-mediated activation
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Adaptive Immune System
Reactome
Apoptosis
Name
Explore in Pharos
Explore in Source
ARMS-mediated activation
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Adaptive Immune System
Apoptosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
2
2
90.2
basophil count
1
1
1
74.3
basophil percentage of leukocytes
1
1
1
74.2
chronotype measurement
2
1
1
1
63.7
blood protein measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
90.2
basophil count
1
74.3
basophil percentage of leukocytes
1
74.2
chronotype measurement
1
1
63.7
blood protein measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
VGNC:10069
458272
Macaque
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
717788
Mouse
MGI:1891917
54401
Rat
RGD:61998
56011
Dog
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
VGNC:48508
477237
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Macaque
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Mouse
Rat
Dog
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Publication Statistics
PubMed Score 143.48
PubMed score by year
PubTator Score 19.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title