Tbio HNRNPH1 Heterogeneous nuclear ribonucleoprotein H

Protein Summary

Description

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• P31943
• B3KW86
• D3DWQ2
• Q6IBM4
• hnRNP H

Gene Name

• HNRNPH1

Ensembl ID

• ENST00000356731
• ENSP00000349168
• ENSG00000169045
• ENST00000393432
• ENSP00000377082
• ENST00000442819
• ENSP00000397797
• ENST00000639490
• ENSP00000492211
• ENSG00000284254
• ENST00000643274
• ENSP00000496484

Symbol

• HNRPH
• HNRPH1
• HNRPH
• HNRPH1
• hnRNPH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.99
transcription factor binding site profile	0.98
transcription factor perturbation	0.91
protein complex	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Heterogeneous Nuclear Ribonucleoprotein H

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Heterogeneous Nuclear Ribonucleoprotein H

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.98   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.98   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0