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Tbio
HNRNPH3
Heterogeneous nuclear ribonucleoprotein H3

Protein Summary
Description
Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced spl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265866
  • ENSP00000265866
  • ENSG00000096746
  • ENST00000354695
  • ENSP00000346726

Symbol
  • HNRPH3
  • 2H9
  • HNRPH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.91
transcription factor binding site profile
0.81
virus perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein H3
VGNC:7277
466093
Macaque
heterogeneous nuclear ribonucleoprotein H3
694760
Mouse
MGI:1926462
432467
Rat
Dog
heterogeneous nuclear ribonucleoprotein H3
VGNC:41732
479227
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein H3
Macaque
heterogeneous nuclear ribonucleoprotein H3
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein H3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31942-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (130)
1 – 10 of 130
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.975
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.974
Data Source: STRINGDB
HNRNPDL
Tbio
Novelty: 0.00222179
Score: 0.954
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.947
Data Source: STRINGDB
HNRNPF
Tbio
Novelty: 0.01833966
Score: 0.894
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.847
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.846
Data Source: STRINGDB
HNRNPUL1
Tbio
Novelty: 0.06289209
Score: 0.842
Data Source: STRINGDB
PTBP1
Tbio
Novelty: 0.00184728
Score: 0.831
Data Source: STRINGDB
HNRNPA0
Tbio
Novelty: 0.10233768
Score: 0.815
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.02

PubMed score by year
PubTator Score  7.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer