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Tchem
APOBEC3A
DNA dC->dU-editing enzyme APOBEC-3A

Protein Summary
Description
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249116
  • ENSP00000249116
  • ENSG00000128383
  • ENST00000402255
  • ENSP00000384359
  • ENST00000570508
  • ENSP00000461288
  • ENSG00000262156
  • ENST00000618553
  • ENSP00000481904
  • ENST00000623492
  • ENSP00000485234

Symbol
  • A3A
  • APOBEC3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.66
microRNA
0.59
virus perturbation
0.59
biological term
0.56
tissue sample
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.05   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.05   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
SID49641938
Rendered image for SID49641938
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
3
61.4
red blood cell distribution width
2
2
3
61.4
sex hormone-binding globulin measurement
2
1
2
12.1
sex hormone-binding globulin measurement
2
1
2
12.1
2
1
0
1.2
10.1
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
61.4
red blood cell distribution width
3
61.4
sex hormone-binding globulin measurement
2
12.1
sex hormone-binding globulin measurement
2
12.1
0
1.2
10.1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31941-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Formation of the Editosome (R-HSA-75094)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of the Editosome
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: C to U Conversion
Name
Explore in Pharos
Explore in Source
Formation of the Editosome
Metabolism of RNA
mRNA Editing
mRNA Editing: C to U Conversion
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (52)
1 – 10 of 52
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.789685768
p_ni:  4.97e-7
p_wrong:  0.210313735
Score:  0.171
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.766428771
p_ni:  0.000004669
p_wrong:  0.23356656
Score:  0.177
Data Source:  BioPlex,STRINGDB
APOBEC4
Tdark
Novelty:  0.13240154
Score:  0.977
Data Source:  STRINGDB
APOBEC1
Tbio
Novelty:  0.00622042
Score:  0.928
Data Source:  STRINGDB
APOBEC3H
Tbio
Novelty:  0.01600106
Score:  0.92
Data Source:  STRINGDB
A1CF
Tbio
Novelty:  0.04151936
Score:  0.92
Data Source:  STRINGDB
APOBEC2
Tbio
Novelty:  0.03447716
Score:  0.919
Data Source:  STRINGDB
APOBEC3C
Tbio
Novelty:  0.00882074
Score:  0.913
Data Source:  STRINGDB
APOBEC3B
Tbio
Novelty:  0.008531
Score:  0.909
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.819
Data Source:  STRINGDB
Publication Statistics
PubMed Score  145.05

PubMed score by year
PubTator Score  3.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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