Tbio HIBADH 3-hydroxyisobutyrate dehydrogenase, mitochondrial

Protein Summary

Description

This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• P31937
• Q546Z2
• Q9UDN3
• HIBADH

Gene Name

• HIBADH

Ensembl ID

• ENST00000265395
• ENSP00000265395
• ENSG00000106049

Symbol

• NS5ATP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
disease perturbation	0.95
histone modification site profile	0.9
transcription factor perturbation	0.88
trait	0.86

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / 3-hydroxyisobutyrate Dehydrogenase, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / 3-hydroxyisobutyrate Dehydrogenase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.13   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.13   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0