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Tbio
HIBADH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

Protein Summary
Description
This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265395
  • ENSP00000265395
  • ENSG00000106049

Symbol
  • NS5ATP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.95
histone modification site profile
0.9
transcription factor perturbation
0.88
trait
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
SERPINF2
Tbio
Novelty:  0.00054719
p_int:  0.998567909
p_ni:  0.00143209
Data Source:  BioPlex
ZNF692
Tbio
Family:  TF
Novelty:  0.07012646
p_int:  0.996730565
p_ni:  0.003269435
Score:  0.325
Data Source:  BioPlex,STRINGDB
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.995883279
p_ni:  0.004116721
Data Source:  BioPlex
CES2
Tchem
Family:  Enzyme
Novelty:  0.00177726
p_int:  0.994535519
p_ni:  0.005464481
Data Source:  BioPlex
ECM1
Tbio
Novelty:  0.00518679
p_int:  0.987877665
p_ni:  0.012122331
p_wrong:  4e-9
Data Source:  BioPlex
CRELD1
Tbio
Novelty:  0.04938248
p_int:  0.874591879
p_ni:  0.125408105
p_wrong:  1.6e-8
Data Source:  BioPlex
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
Score:  0.997
Data Source:  STRINGDB
HIBCH
Tbio
Family:  Enzyme
Novelty:  0.02964018
Score:  0.994
Data Source:  STRINGDB
ALDH1B1
Tchem
Family:  Enzyme
Novelty:  0.01755208
Score:  0.956
Data Source:  STRINGDB
AGXT2
Tbio
Family:  Enzyme
Novelty:  0.02018289
Score:  0.953
Data Source:  STRINGDB
Pathways (8)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
78.5
2
2
0
1.1
57.1
intelligence
1
1
1
53.7
1
1
0
1.3
51.7
risk-taking behaviour
2
2
2
43.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
78.5
0
1.1
57.1
intelligence
1
53.7
0
1.3
51.7
risk-taking behaviour
2
43.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3-hydroxyisobutyrate dehydrogenase
VGNC:4386
463313
Macaque
3-hydroxyisobutyrate dehydrogenase
702794
Mouse
MGI:1889802
58875
Rat
RGD:708399
63938
Dog
3-hydroxyisobutyrate dehydrogenase
479610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3-hydroxyisobutyrate dehydrogenase
Macaque
3-hydroxyisobutyrate dehydrogenase
Mouse
Rat
Dog
3-hydroxyisobutyrate dehydrogenase
Publication Statistics
PubMed Score 27.68
PubMed score by year
PubTator Score 8.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title