You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UQCRC1
Cytochrome b-c1 complex subunit 1, mitochondrial

Protein Summary
Description
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000203407
  • ENSP00000203407
  • ENSG00000010256

Symbol
  • QCR1
  • UQCR1
  • D3S3191
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
disease perturbation
0.9
interacting protein
0.82
histone modification site profile
0.78
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (223)
UQCRQ
Tbio
Novelty:  0.04392627
p_int:  0.995885314
p_ni:  0.004114686
Score:  0.999
Data Source:  BioPlex,STRINGDB
UQCRB
Tbio
Novelty:  0.02933046
p_int:  0.983994065
p_ni:  0.016005935
Score:  0.999
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.971537842
p_ni:  0.028462158
Score:  0.968
Data Source:  BioPlex,STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
p_int:  0.968308244
p_ni:  0.031691756
Score:  0.441
Data Source:  BioPlex,STRINGDB
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
p_int:  0.880628363
p_ni:  0.119371637
Score:  0.91
Data Source:  BioPlex,STRINGDB
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.879320603
p_ni:  0.120679397
Score:  0.999
Data Source:  BioPlex,STRINGDB
UQCR10
Tbio
Novelty:  0.04536078
Score:  0.999
Data Source:  STRINGDB
CYC1
Tchem
Novelty:  0.01369865
Score:  0.999
Data Source:  STRINGDB
UQCRFS1
Tbio
Novelty:  0.00341256
Score:  0.999
Data Source:  STRINGDB
UQCR11
Tbio
Novelty:  0.08583842
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
3
3
87
self reported educational attainment
4
5
4
5.9
84.4
mathematical ability
2
3
3
81.7
BMI-adjusted waist-hip ratio
2
2
2
79.7
waist-hip ratio
2
3
3
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
87
self reported educational attainment
4
5.9
84.4
mathematical ability
3
81.7
BMI-adjusted waist-hip ratio
2
79.7
waist-hip ratio
3
75.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase core protein 1
VGNC:48908
460348
Macaque
ubiquinol-cytochrome c reductase core protein I
677864
Mouse
MGI:107876
22273
Rat
RGD:1303314
301011
Dog
ubiquinol-cytochrome c reductase core protein 1
VGNC:48163
608455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase core protein 1
Macaque
ubiquinol-cytochrome c reductase core protein I
Mouse
Rat
Dog
ubiquinol-cytochrome c reductase core protein 1
Publication Statistics
PubMed Score 64.89
PubMed score by year
PubTator Score 10.37
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title