Tbio UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial

Protein Summary

Description

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Uniprot Accession IDs

• P31930
• B2R7R8
• Q96DD2

Gene Name

• UQCRC1

Ensembl ID

• ENST00000203407
• ENSP00000203407
• ENSG00000010256

Symbol

• QCR1
• UQCR1
• D3S3191

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
disease perturbation	0.9
interacting protein	0.82
histone modification site profile	0.78
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Cytochrome B-c1 Complex Subunit 1, Mitochondrial

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Cytochrome B-c1 Complex Subunit 1, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.28   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 312   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.28   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0