You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
IL2RG
Cytokine receptor common subunit gamma

Protein Summary
Description
Common subunit for the receptors for a variety of interleukins. The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374202
  • ENSP00000363318
  • ENSG00000147168
  • ENST00000456850
  • ENSP00000388967

Symbol
  • P64
  • CIDX
  • IMD4
  • CD132
  • SCIDX
  • IL-2RG
  • SCIDX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
disease perturbation
0.97
phenotype
0.7
biological term
0.66
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.97   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 564   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.97   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4