IL2RG
Cytokine receptor common subunit gamma
Protein Summary
Common subunit for the receptors for a variety of interleukins. The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
- ENST00000374202
- ENSP00000363318
- ENSG00000147168
- ENST00000456850
- ENSP00000388967
- P64
- CIDX
- IMD4
- CD132
- SCIDX
- IL-2RG
- SCIDX1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.98 | ||
disease perturbation | 0.97 | ||
phenotype | 0.7 | ||
biological term | 0.66 | ||
cellular component | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1145.97 (req: < 5)
Gene RIFs: 76 (req: <= 3)
Antibodies: 564 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1145.97 (req: >= 5)
Gene RIFs: 76 (req: > 3)
Antibodies: 564 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4