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Tchem
AKT2
RAC-beta serine/threonine-protein kinase

Protein Summary
Description
AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycog ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311278
  • ENSP00000309428
  • ENSG00000105221
  • ENST00000392038
  • ENSP00000375892
  • ENST00000424901
  • ENSP00000399532

Symbol
  • PKBB
  • PRKBB
  • HIHGHH
  • PKBBETA
  • RAC-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.99
protein domain
0.99
transcription factor perturbation
0.98
hub protein
0.96


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 608.78   (req: < 5)
Gene RIFs: 206   (req: <= 3)
Antibodies: 1474   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 608.78   (req: >= 5)
Gene RIFs: 206   (req: > 3)
Antibodies: 1474   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 302
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0