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Tchem
AKT2
RAC-beta serine/threonine-protein kinase

Protein Classes
Protein Summary
Description
AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycog ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311278
  • ENSP00000309428
  • ENSG00000105221
  • ENST00000392038
  • ENSP00000375892
  • ENST00000424901
  • ENSP00000399532

Symbol
  • PKBB
  • PRKBB
  • HIHGHH
  • PKBBETA
  • RAC-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.99
protein domain
0.99
transcription factor perturbation
0.98
hub protein
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 521.93   (req: < 5)
Gene RIFs: 206   (req: <= 3)
Antibodies: 1474   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 521.93   (req: >= 5)
Gene RIFs: 206   (req: > 3)
Antibodies: 1474   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 286
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
28
monocyte count
1
1
1
23.7
lymphocyte count
1
1
1
23.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
28
monocyte count
1
23.7
lymphocyte count
1
23.7
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (262)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 87
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
AKT phosphorylates targets in the nucleus
Reactome
AKT-mediated inactivation of FOXO1A
Reactome
Activation of AKT2
Reactome
Activation of BAD and translocation to mitochondria
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
Activation of AKT2
Activation of BAD and translocation to mitochondria
Gene Ontology Terms (46)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (324)
1 – 10 of 324
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
UBE2O
Tbio
Novelty: 0.07084123
p_int: 0.995490647
p_ni: 0.004509353
Score: 0.26
Data Source: BioPlex,STRINGDB
CDK3
Tchem
Family: Kinase
Novelty: 0.03380289
p_int: 0.992789696
p_ni: 0.007210304
Score: 0.324
Data Source: BioPlex,STRINGDB
PSMD9
Tbio
Family: Enzyme
Novelty: 0.02173534
p_int: 0.985642993
p_ni: 0.014353548
p_wrong: 0.000003459
Score: 0.46
Data Source: BioPlex,STRINGDB
NR2F2
Tbio
Family: NR
Novelty: 0.00450561
p_int: 0.983962529
p_ni: 0.014126854
p_wrong: 0.001910617
Score: 0.259
Data Source: BioPlex,STRINGDB
TPM2
Tbio
Novelty: 0.00406572
p_int: 0.967586478
p_ni: 0.032413515
p_wrong: 7e-9
Score: 0.152
Data Source: BioPlex,STRINGDB
USP9Y
Tdark
Family: Enzyme
p_int: 0.922537469
p_ni: 0.077444644
p_wrong: 0.000017888
Data Source: BioPlex
FAT3
Tbio
Novelty: 0.03661008
p_int: 0.9106543
p_ni: 0.0893457
Score: 0.204
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.891843071
p_ni: 0.108156929
Score: 0.168
Data Source: BioPlex,STRINGDB
NSMCE4A
Tdark
Novelty: 0.45550673
p_int: 0.778340111
p_ni: 0.212425301
p_wrong: 0.009234588
Score: 0.175
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  521.93

PubMed score by year
PubTator Score  382.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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