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Tchem
AKT1
RAC-alpha serine/threonine-protein kinase

Protein Classes
Protein Summary
Description
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycog ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349310
  • ENSP00000270202
  • ENSG00000142208
  • ENST00000402615
  • ENSP00000385326
  • ENST00000407796
  • ENSP00000384293
  • ENST00000554581
  • ENSP00000451828
  • ENST00000554848
  • ENSP00000451166
  • ENST00000555528
  • ENSP00000450688
  • ENST00000649815
  • ENSP00000497822

Symbol
  • PKB
  • RAC
  • AKT
  • PKB
  • RAC
  • CWS6
  • PRKBA
  • PKB-ALPHA
  • RAC-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
kinase
1


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29775.56   (req: < 5)
Gene RIFs: 2608   (req: <= 3)
Antibodies: 4668   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29775.56   (req: >= 5)
Gene RIFs: 2608   (req: > 3)
Antibodies: 4668   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 157
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1025
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
2
2
74.7
apolipoprotein A 1 measurement
1
1
1
66.3
sex hormone-binding globulin measurement
4
1
4
63.8
1
1
0
1.1
28.5
endometrial endometrioid carcinoma
1
1
0
1.1
28.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
74.7
apolipoprotein A 1 measurement
1
66.3
sex hormone-binding globulin measurement
4
63.8
0
1.1
28.5
endometrial endometrioid carcinoma
0
1.1
28.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
AKT serine/threonine kinase 1
697747
Mouse
MGI:87986
11651
Rat
RGD:2081
24185
Dog
AKT serine/threonine kinase 1
VGNC:37770
490878
Horse
AKT serine/threonine kinase 1
VGNC:15217
100061130
Species
Name
OMA
EggNOG
Inparanoid
Macaque
AKT serine/threonine kinase 1
Mouse
Rat
Dog
AKT serine/threonine kinase 1
Horse
AKT serine/threonine kinase 1
Protein Structure (25 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31749-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (417)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 97
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
AKT phosphorylates targets in the nucleus
Reactome
AKT-mediated inactivation of FOXO1A
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Gene Ontology Terms (170)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Protein-Protein Interactions (1761)
1 – 10 of 1761
AKT2
Tchem
Family: Kinase
Novelty: 0.00167027
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
AKT3
Tchem
Family: Kinase
Novelty: 0.00308931
p_int: 1
Score: 0.931
Data Source: BioPlex,STRINGDB
NR2F2
Tbio
Family: NR
Novelty: 0.00450561
p_int: 0.999968208
p_ni: 0.000031792
Score: 0.849
Data Source: BioPlex,STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00095115
Score: 0.999
Data Source: Reactome,STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.999
Data Source: Reactome,STRINGDB
FOXO3
Tbio
Family: TF
Novelty: 0.00074316
Score: 0.999
Data Source: Reactome,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
Score: 0.999
Data Source: STRINGDB
NOS3
Tchem
Family: Enzyme
Novelty: 0.00012407
Score: 0.999
Data Source: Reactome,STRINGDB
PDPK1
Tchem
Family: Kinase
Novelty: 0.00430458
Score: 0.999
Data Source: Reactome,STRINGDB
FOXO1
Tbio
Family: TF
Novelty: 0.00058938
Score: 0.998
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  29775.56

PubMed score by year
PubTator Score  11900.14

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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