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Tchem
DNAJA1
DnaJ homolog subfamily A member 1

Protein Summary
Description
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330899
  • ENSP00000369127
  • ENSG00000086061

Symbol
  • DNAJ2
  • HDJ2
  • HSJ2
  • HSPF4
  • DJ-2
  • DjA1
  • HDJ2
  • HSDJ
  • HSJ2
  • HSJ-2
  • HSPF4
  • NEDD7
  • hDJ-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.98
molecular function
0.98
disease perturbation
0.97
protein complex
0.96


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.28   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.28   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member A1
VGNC:4707
746627
Macaque
DnaJ heat shock protein family (Hsp40) member A1
703765
Mouse
MGI:1270129
15502
Rat
RGD:620942
65028
Dog
DnaJ heat shock protein family (Hsp40) member A1
VGNC:51708
100855671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member A1
Macaque
DnaJ heat shock protein family (Hsp40) member A1
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member A1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31689-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Gene Ontology Terms (35)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (156)
1 – 10 of 156
ENDOG
Tbio
Family: Enzyme
Novelty: 0.00404275
p_int: 0.999979534
p_ni: 0.000020466
Score: 0.267
Data Source: BioPlex,STRINGDB
OSBPL9
Tbio
Novelty: 0.07633459
p_int: 0.999778276
p_ni: 0.000205877
p_wrong: 0.000015847
Score: 0.332
Data Source: BioPlex,STRINGDB
OSBPL11
Tbio
Novelty: 0.17706694
p_int: 0.997247518
p_ni: 0.002752482
Score: 0.309
Data Source: BioPlex,STRINGDB
HERC2
Tbio
Family: Enzyme
Novelty: 0.06552683
p_int: 0.987759128
p_ni: 0.012240872
Score: 0.18
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
Score: 0.996
Data Source: Reactome,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.993
Data Source: Reactome,STRINGDB
HSPA1A
Tchem
Novelty: 0.00069195
Score: 0.989
Data Source: Reactome,STRINGDB
HSPH1
Tbio
Novelty: 0.01617555
Score: 0.986
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.985
Data Source: STRINGDB
STIP1
Tbio
Novelty: 0.00590952
Score: 0.979
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  107.28

PubMed score by year
PubTator Score  63.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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