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Tchem
DNAJA1
DnaJ homolog subfamily A member 1

Protein Summary
Description
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330899
  • ENSP00000369127
  • ENSG00000086061

Symbol
  • DNAJ2
  • HDJ2
  • HSJ2
  • HSPF4
  • DJ-2
  • DjA1
  • HDJ2
  • HSDJ
  • HSJ2
  • HSJ-2
  • HSPF4
  • NEDD7
  • hDJ-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.98
molecular function
0.98
disease perturbation
0.97
protein complex
0.96


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.99   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.99   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0