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Tclin
GABRA5
Gamma-aminobutyric acid receptor subunit alpha-5

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335625
  • ENSP00000335592
  • ENSG00000186297
  • ENST00000355395
  • ENSP00000347557
  • ENST00000400081
  • ENSP00000382953
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.97
molecular function
0.93
protein domain
0.92
gene perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.9   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.9   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 449
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 25
Approved Drugs (25)
1 – 10 of 25
halothane
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isoflurane
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desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
triclofos
Rendered image for triclofos
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
63.7
mathematical ability
1
1
1
53.7
cognitive function measurement
1
1
1
49.5
Hepatitis
1
1
0
1
27.3
body mass index
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
63.7
mathematical ability
1
53.7
cognitive function measurement
1
49.5
Hepatitis
0
1
27.3
body mass index
1
17.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor alpha5 subunit
VGNC:13402
744855
Macaque
gamma-aminobutyric acid type A receptor alpha5 subunit
711838
Mouse
MGI:95617
110886
Rat
RGD:61859
29707
Dog
gamma-aminobutyric acid type A receptor alpha5 subunit
VGNC:41057
488688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor alpha5 subunit
Macaque
gamma-aminobutyric acid type A receptor alpha5 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor alpha5 subunit
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31644-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (125)
1 – 10 of 125
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
p_int:  0.999999941
p_wrong:  5.9e-8
Score:  0.937
Data Source:  BioPlex,STRINGDB
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.986
Data Source:  STRINGDB
GABRB3
Tclin
Family:  IC
Novelty:  0.00485997
Score:  0.981
Data Source:  STRINGDB
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
Score:  0.98
Data Source:  STRINGDB
GABRB1
Tclin
Family:  IC
Novelty:  0.02895574
Score:  0.978
Data Source:  STRINGDB
GPHN
Tbio
Novelty:  0.0020752
Score:  0.949
Data Source:  STRINGDB
GABRQ
Tclin
Family:  IC
Novelty:  0.12221217
Score:  0.94
Data Source:  STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.939
Data Source:  STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
Score:  0.935
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.929
Data Source:  STRINGDB
Publication Statistics
PubMed Score  66.90

PubMed score by year
PubTator Score  31.9

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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