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Tclin
GABRA5
Gamma-aminobutyric acid receptor subunit alpha-5

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335625
  • ENSP00000335592
  • ENSG00000186297
  • ENST00000355395
  • ENSP00000347557
  • ENST00000400081
  • ENSP00000382953
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.97
molecular function
0.93
protein domain
0.92
gene perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.07   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.07   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 439
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 24
Approved Drugs (24)
1 – 10 of 24
triazolam
chemical structure image
diazepam
chemical structure image
halothane
chemical structure image
flumazenil
chemical structure image
midazolam
chemical structure image
isoflurane
chemical structure image
zopiclone
chemical structure image
desflurane
chemical structure image
sevoflurane
chemical structure image
eszopiclone
chemical structure image
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (125)
1 – 10 of 125
GABRA3
Tclin
Family: IC
Novelty: 0.02180091
p_int: 0.999999941
p_wrong: 5.9e-8
Score: 0.937
Data Source: BioPlex,STRINGDB
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
Score: 0.986
Data Source: STRINGDB
GABRB3
Tclin
Family: IC
Novelty: 0.00485997
Score: 0.981
Data Source: STRINGDB
GABRB2
Tclin
Family: IC
Novelty: 0.01954146
Score: 0.98
Data Source: STRINGDB
GABRB1
Tclin
Family: IC
Novelty: 0.02895574
Score: 0.978
Data Source: STRINGDB
GPHN
Tbio
Novelty: 0.0020752
Score: 0.949
Data Source: STRINGDB
GABRQ
Tclin
Family: IC
Novelty: 0.12221217
Score: 0.94
Data Source: STRINGDB
GABRA1
Tclin
Family: IC
Novelty: 0.0094079
Score: 0.939
Data Source: STRINGDB
GABARAP
Tbio
Novelty: 0.00444901
Score: 0.935
Data Source: STRINGDB
GABRA6
Tclin
Family: IC
Novelty: 0.02894664
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.07

PubMed score by year
PubTator Score  31.9

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer