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Tbio
FMO3
Dimethylaniline monooxygenase [N-oxide-forming] 3

Protein Summary
Description
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773). Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression le ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367755
  • ENSP00000356729
  • ENSG00000007933

Symbol
  • TMAU
  • FMOII
  • dJ127D3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
molecular function
0.79
cell type or tissue
0.7
biological term
0.62
cellular component
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.07   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.07   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
81.2
blood metabolite measurement
1
1
1
59.6
testosterone measurement
1
1
1
48.5
lentiform nucleus measurement
1
1
0
112.3
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
81.2
blood metabolite measurement
1
59.6
testosterone measurement
1
48.5
lentiform nucleus measurement
0
112.3
0.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 3
VGNC:544
457505
Macaque
flavin containing monooxygenase 3
574244
Mouse
MGI:1100496
14262
Rat
RGD:619761
84493
Dog
flavin containing monooxygenase 3
VGNC:40918
403603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 3
Macaque
flavin containing monooxygenase 3
Mouse
Rat
Dog
flavin containing monooxygenase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31513-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective FMO3 causes Trimethylaminuria (TMAU)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
FMO oxidises nucleophiles
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective FMO3 causes Trimethylaminuria (TMAU)
Disease
Diseases of metabolism
FMO oxidises nucleophiles
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (49)
1 – 10 of 49
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
p_int:  0.873390509
p_ni:  0.126608391
p_wrong:  0.0000011
Data Source:  BioPlex
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.967
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.961
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.954
Data Source:  STRINGDB
DMGDH
Tbio
Family:  Enzyme
Novelty:  0.03936436
Score:  0.811
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.731
Data Source:  STRINGDB
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.666
Data Source:  STRINGDB
CYP2A6
Tchem
Novelty:  0.00105285
Score:  0.641
Data Source:  STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
Score:  0.628
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.626
Data Source:  STRINGDB
Publication Statistics
PubMed Score  193.07

PubMed score by year
PubTator Score  206.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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