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Tbio
TIA1
Nucleolysin TIA-1 isoform p40

Protein Summary
Description
Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000415783
  • ENSP00000404023
  • ENSG00000116001
  • ENST00000416149
  • ENSP00000413751
  • ENST00000433529
  • ENSP00000401371

Symbol
  • WDM
  • TIA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.96
transcription factor perturbation
0.91
microRNA
0.89
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 373.49   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 483   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 373.49   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 483   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
90.6
mean corpuscular volume
1
1
1
78.6
leukocyte count
1
1
1
71.6
neutrophil count
2
2
2
68.5
alkaline phosphatase measurement
1
1
1
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
90.6
mean corpuscular volume
1
78.6
leukocyte count
1
71.6
neutrophil count
2
68.5
alkaline phosphatase measurement
1
65.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TIA1 cytotoxic granule associated RNA binding protein
459303
Macaque
TIA1 cytotoxic granule associated RNA binding protein
702366
Mouse
MGI:107914
21841
Rat
RGD:1305742
312510
Dog
TIA1 cytotoxic granule associated RNA binding protein
VGNC:47363
610625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TIA1 cytotoxic granule associated RNA binding protein
Macaque
TIA1 cytotoxic granule associated RNA binding protein
Mouse
Rat
Dog
TIA1 cytotoxic granule associated RNA binding protein
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P31483-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR2
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Signal Transduction
Signaling by FGFR
Signaling by FGFR2
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (202)
1 – 10 of 202
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.949
Data Source:  STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.949
Data Source:  STRINGDB
HNRNPF
Tbio
Novelty:  0.01833966
Score:  0.938
Data Source:  STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.937
Data Source:  STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
Score:  0.936
Data Source:  STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
Score:  0.931
Data Source:  STRINGDB
ESRP1
Tbio
Novelty:  0.02035464
Score:  0.931
Data Source:  STRINGDB
DHX9
Tbio
Family:  Enzyme
Novelty:  0.00130907
Score:  0.928
Data Source:  STRINGDB
ESRP2
Tbio
Novelty:  0.05084007
Score:  0.928
Data Source:  STRINGDB
NCBP2
Tbio
Novelty:  0.01426734
Score:  0.924
Data Source:  STRINGDB
Publication Statistics
PubMed Score  373.49

PubMed score by year
PubTator Score  339.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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