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Tbio
SDC4
Syndecan-4

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372733
  • ENSP00000361818
  • ENSG00000124145

Symbol
  • SYND4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.98
kinase perturbation
0.97
biological process
0.93
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.99   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.99   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (206)
1 – 10 of 206
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.999998811
p_ni:  1.11e-7
p_wrong:  0.000001078
Data Source:  BioPlex
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.999990205
p_ni:  0.000004993
p_wrong:  0.000004802
Data Source:  BioPlex
FGF1
Tchem
Novelty:  0.00055979
p_int:  0.999914402
p_ni:  0.000037481
p_wrong:  0.000048117
Score:  0.634
Data Source:  BioPlex,STRINGDB
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.998242248
p_ni:  0.000003947
p_wrong:  0.001753805
Score:  0.222
Data Source:  BioPlex,STRINGDB
SDCBP
Tbio
Novelty:  0.00242211
Score:  0.999
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.986
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.983
Data Source:  STRINGDB
GIPC1
Tbio
Novelty:  0.00862
Score:  0.981
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.979
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.973
Data Source:  STRINGDB
Pathways (46)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Cell surface interactions at the vascular wall
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Cell surface interactions at the vascular wall
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
15.8
free cholesterol measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
15.8
free cholesterol measurement
1
15.8
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1349164
20971
Rat
RGD:3650
24771
Dog
syndecan 4
VGNC:45944
485893
Horse
syndecan 4
VGNC:22764
100070934
Cow
syndecan 4
VGNC:34381
508133
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
syndecan 4
Horse
syndecan 4
Cow
syndecan 4
Publication Statistics
PubMed Score 357.99
PubMed score by year
PubTator Score 260.86
PubTator score by year