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Tbio
SDC4
Syndecan-4

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372733
  • ENSP00000361818
  • ENSG00000124145

Symbol
  • SYND4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.98
kinase perturbation
0.97
biological process
0.93
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.26   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.26   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (46)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Cell surface interactions at the vascular wall
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Cell surface interactions at the vascular wall
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Protein-Protein Interactions (206)
1 – 10 of 206
HADHA
Tbio
Novelty: 0.00234785
p_int: 0.999998811
p_ni: 1.11e-7
p_wrong: 0.000001078
Data Source: BioPlex
EVA1B
Tdark
Novelty: 3
p_int: 0.999990205
p_ni: 0.000004993
p_wrong: 0.000004802
Data Source: BioPlex
FGF1
Tchem
Novelty: 0.00060955
p_int: 0.999914402
p_ni: 0.000037481
p_wrong: 0.000048117
Score: 0.634
Data Source: BioPlex,STRINGDB
GPR183
Tchem
Family: GPCR
Novelty: 0.021257
p_int: 0.998242248
p_ni: 0.000003947
p_wrong: 0.001753805
Score: 0.222
Data Source: BioPlex,STRINGDB
SDCBP
Tbio
Novelty: 0.0034118
Score: 0.999
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.0000437
Score: 0.986
Data Source: STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00099987
Score: 0.983
Data Source: STRINGDB
GIPC1
Tbio
Novelty: 0.00821824
Score: 0.981
Data Source: STRINGDB
FGF2
Tchem
Novelty: 0.00009754
Score: 0.979
Data Source: STRINGDB
GPC1
Tbio
Novelty: 0.00384835
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  268.26

PubMed score by year
PubTator Score  260.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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